NBP2 Nbp2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: NBP2
Official Full Name: Nbp2p
Primary source: SGD:S000002569
Locus tag: YDR162C
See related: AllianceGenome:SGD:S000002569; FungiDB:YDR162C; VEuPathDB:YDR162C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein-macromolecule adaptor activity. Involved in fungal-type cell wall organization or biogenesis and negative regulation of MAPK cascade. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Nbp2p SH3 domain made contacts with the Ste20 peptide core RXXPXXP motif and the Bem1p SH3b domain made stronger contacts with residues flanking the core motif.
Title: Distinct peptide binding specificities of Src homology 3 (SH3) protein domains can be determined by modulation of local energetics across the binding interface.
Nbp2 serves as the network hub and brings seven kinases in close contact to Ptc1.
Title: A constraint network of interactions: protein-protein interaction analysis of the yeast type II phosphatase Ptc1p and its adaptor protein Nbp2p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fungal-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

NP_010446.3

Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p to the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm; contains an SH3 domain and a Ptc1p binding domain (PBM)

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The following sections contain reference sequences that belong to a specific genome build. Explain