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    DSS1 exoribonuclease II [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DSS1
    Official Full Name
    exoribonuclease II
    Primary source
    SGD:S000004900
    Locus tag
    YMR287C
    See related
    AllianceGenome:SGD:S000004900; FungiDB:YMR287C; VEuPathDB:YMR287C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MSU1
    Summary
    Enables exoribonuclease II activity. Involved in mitochondrial RNA catabolic process. Located in mitochondrion. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DSS1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (842436..845345, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene RNA exonuclease Neighboring gene mitochondrial 54S ribosomal protein YmL33 Neighboring gene U2 snRNP complex subunit HSH155 Neighboring gene aminodeoxychorismate lyase ABZ2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components. Razew M, et al. Nat Commun, 2018 Jan 8. PMID 29311576, Free PMC Article
    2. Isolation and characterization of an NTP-dependent 3'-exoribonuclease from mitochondria of Saccharomyces cerevisiae. Min J, et al. J Biol Chem, 1993 Apr 5. PMID 8385104
    3. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. Guo XE, et al. J Biol Chem, 2011 Nov 4. PMID 21911497, Free PMC Article
    4. Role of Rmd9p in 3'-end processing of mitochondrial 15S rRNA in Saccharomyces cerevisiae. Singh J, et al. Mitochondrion, 2024 May. PMID 38599301
    5. Assays of the helicase, ATPase, and exoribonuclease activities of the yeast mitochondrial degradosome. Malecki M, et al. Methods Mol Biol, 2010. PMID 20225161

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data enabled the discovery of links between components of the mRNA export and splicing machineries and Sem1/Dss1, a component of the 19S proteasome.
      Title: A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exoribonuclease II activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exoribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial RNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial degradosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exoribonuclease II
    NP_014014.1
    • 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      842436..845345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182794.1 → NP_014014.1  TPA: exoribonuclease II [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0B4, P39112
      UniProtKB/TrEMBL
      G2WKZ6, N1P614
      Conserved Domains (1) summary
      COG0557
      Location:385 → 967
      VacB; Exoribonuclease R [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39112.2

    Gene LinkOut

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