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    SSO2 syntaxin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SSO2
    Official Full Name
    syntaxin
    Primary source
    SGD:S000004795
    Locus tag
    YMR183C
    See related
    AllianceGenome:SGD:S000004795; FungiDB:YMR183C; VEuPathDB:YMR183C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity and phosphatidic acid binding activity. Involved in ascospore-type prospore assembly. Located in plasma membrane and prospore membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Hirschsprung's disease; congenital diarrhea; familial hemophagocytic lymphohistiocytosis 4; and generalized epilepsy with febrile seizures plus 9. Orthologous to several human genes including STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SSO2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (626921..627808, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Min3p Neighboring gene ncRNA Neighboring gene Add37p Neighboring gene Rtp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane insertion and intracellular transport of yeast syntaxin Sso2p in mammalian cells. Jäntti J, et al. J Cell Sci, 1994 Dec. PMID 7706411
    2. Development of a Saccharomyces cerevisiae strain with enhanced resistance to phenolic fermentation inhibitors in lignocellulose hydrolysates by heterologous expression of laccase. Larsson S, et al. Appl Environ Microbiol, 2001 Mar. PMID 11229906, Free PMC Article
    3. SNAREs and the secretory pathway-lessons from yeast. Pelham HR. Exp Cell Res, 1999 Feb 25. PMID 10047442
    4. Enhancement of protein secretion in Saccharomyces cerevisiae by overproduction of Sso protein, a late-acting component of the secretory machinery. Ruohonen L, et al. Yeast, 1997 Mar 30. PMID 9133737
    5. Mapping of sporulation-specific functions in the yeast syntaxin gene SSO1. Oyen M, et al. Curr Genet, 2004 Feb. PMID 14652692

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggested that Sso2p plays a role in maintaining the lipid composition of the plasma membrane and the increase in unsaturated fatty acids amplified the production of ROS in the acute phase of aluminium stress. ROS derived from aluminium stress inhibited growth and resulted in the susceptibility of the Deltasso2 strain.
      Title: Decreased aluminium tolerance in the growth of Saccharomyces cerevisiae with SSO2 gene disruption.
    2. Data indicate the binding kinetic properties of three SNAREs: Sec22p, Ykt6p and Sso2p.
      Title: Analysis of interactions between SNARE proteins using imaging ellipsometer coupled with microfluidic array.
    3. The Sso1, but not SSo2, is essential for prospore membrane formation.
      Title: Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNAP receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ascospore-type prospore assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syntaxin
    NP_013908.1
    • Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      626921..627808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182689.1 → NP_013908.1  TPA: syntaxin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W007, P39926
      UniProtKB/TrEMBL
      A6ZMP4, B3LM70, C7GTR7, C8ZF47, G2WKN8, N1NYJ6
      Conserved Domains (1) summary
      COG5074
      Location:1 → 280
      COG5074; t-SNARE complex subunit, syntaxin [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39926.2

    Gene LinkOut

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