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    Golm2 golgi membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 319996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golm2provided by MGI
    Official Full Name
    golgi membrane protein 2provided by MGI
    Primary source
    MGI:MGI:2443129
    See related
    Ensembl:ENSMUSG00000060227 AllianceGenome:MGI:2443129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Casc4; VGFG2573; D130060C09Rik
    Summary
    Predicted to be located in Golgi apparatus. Is expressed in genitourinary system. Orthologous to human GOLM2 (golgi membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 11.0), frontal lobe adult (RPKM 9.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golm2 in Genome Data Viewer
    Location:
    2 E5; 2 60.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121696255..121766701)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121866970..121936220)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene FERM domain containing 5 Neighboring gene septin 2 pseudogene Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene STARR-seq mESC enhancer starr_05538 Neighboring gene STARR-seq mESC enhancer starr_05541 Neighboring gene STARR-seq mESC enhancer starr_05542 Neighboring gene STARR-seq mESC enhancer starr_05544 Neighboring gene STARR-seq mESC enhancer starr_05545 Neighboring gene predicted gene, 39916 Neighboring gene CTD small phosphatase like 2 Neighboring gene MAGE family member B3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein GOLM2
    Names
    cancer susceptibility candidate 4
    cancer susceptibility candidate gene 4 protein homolog
    protein CASC4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205369.1 → NP_001192298.1  protein GOLM2 isoform 3

      See identical proteins and their annotated locations for NP_001192298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
      Source sequence(s)
      AL845286, BC064446
      Consensus CDS
      CCDS57183.1
      UniProtKB/Swiss-Prot
      A2AR57, Q6P2L7, Q6RZW5, Q6RZW6, Q8C4Z2
      Related
      ENSMUSP00000077811.4, ENSMUST00000078752.10
      Conserved Domains (1) summary
      cl19219
      Location:118 → 200
      DUF342; Protein of unknown function (DUF342)

    2. NM_001205370.1 → NP_001192299.1  protein GOLM2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon but includes a different in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL845286
      Consensus CDS
      CCDS57184.1
      UniProtKB/TrEMBL
      E9PZJ6
      Related
      ENSMUSP00000106216.4, ENSMUST00000110586.10
      Conserved Domains (1) summary
      cl19219
      Location:118 → 200
      DUF342; Protein of unknown function (DUF342)

    3. NM_001205371.1 → NP_001192300.1  protein GOLM2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, and contains an alternate in-frame coding exon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK131751, AL845286
      UniProtKB/TrEMBL
      A2AR60
      Related
      ENSMUSP00000117883.2, ENSMUST00000136023.2
      Conserved Domains (1) summary
      cl19219
      Location:2 → 81
      DUF342; Protein of unknown function (DUF342)

    4. NM_177054.5 → NP_796028.2  protein GOLM2 isoform 1

      See identical proteins and their annotated locations for NP_796028.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AY484583, BC064446, BP765295
      Consensus CDS
      CCDS16650.1
      UniProtKB/Swiss-Prot
      Q6P2L7
      Related
      ENSMUSP00000087357.6, ENSMUST00000089912.12
      Conserved Domains (1) summary
      cl19219
      Location:118 → 200
      DUF342; Protein of unknown function (DUF342)

    5. NM_199038.3 → NP_950239.2  protein GOLM2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI848011, AK080364, AY484583, BC064446, BP765295
      Consensus CDS
      CCDS50686.1
      UniProtKB/Swiss-Prot
      Q6P2L7
      Related
      ENSMUSP00000087360.4, ENSMUST00000089915.10
      Conserved Domains (1) summary
      cl19219
      Location:118 → 200
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121696255..121766701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162294.1 → XP_036018187.1  protein GOLM2 isoform X1

      Conserved Domains (1) summary
      TIGR02168
      Location:42 → 195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_036162295.1 → XP_036018188.1  protein GOLM2 isoform X2

      Conserved Domains (1) summary
      TIGR02168
      Location:42 → 195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P2L7.1 GenPept UniProtKB/Swiss-Prot:Q6P2L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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