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    Stard9 StAR related lipid transfer domain containing 9 [ Mus musculus (house mouse) ]

    Gene ID: 668880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stard9provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 9provided by MGI
    Primary source
    MGI:MGI:3045258
    See related
    Ensembl:ENSMUSG00000033705 AllianceGenome:MGI:3045258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kif16a; mKIAA1300; 4831403C07Rik; E230025N21Rik
    Summary
    Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in spindle assembly. Predicted to be active in centriole; cytoplasm; and nucleus. Orthologous to human STARD9 (StAR related lipid transfer domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.2), testis adult (RPKM 4.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stard9 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120459567..120562371)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120629086..120729033)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene synaptosomal-associated protein 23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene STARR-seq mESC enhancer starr_05516 Neighboring gene STARR-positive B cell enhancer ABC_E3396 Neighboring gene expressed sequence AV039307 Neighboring gene ubiquitin protein ligase E3 component n-recognin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kinesin motor KIF16A regulates microtubule stability and actin-dependent spindle migration in mouse oocyte meiosis. Wang W, et al. FASEB J, 2024 Jul 15. PMID 38888878
    2. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival. Sterling FR, et al. J Cell Sci, 2023 Mar 1. PMID 36861884, Free PMC Article
    3. Sequence and expression of murine type I hair keratins mHa2 and mHa3. Winter H, et al. Exp Cell Res, 1994 Jun. PMID 7514534
    4. Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. Nakagawa T, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275178, Free PMC Article
    5. All kinesin superfamily protein, KIF, genes in mouse and human. Miki H, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416179, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin motor KIF16A regulates microtubule stability and actin-dependent spindle migration in mouse oocyte meiosis.
      Title: Kinesin motor KIF16A regulates microtubule stability and actin-dependent spindle migration in mouse oocyte meiosis.
    2. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.
      Title: StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 9
    Names
    N-3 kinesin
    START domain containing 9
    START domain-containing protein 9
    kinesin 16A
    kinesin family member 16A
    kinesin-like protein Kif16a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370940.1 → NP_001357869.1  stAR-related lipid transfer protein 9

      Status: VALIDATED

      Source sequence(s)
      AL772299, AL935168
      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Related
      ENSMUSP00000136055.2, ENSMUST00000180041.9
      Conserved Domains (4) summary
      cd00060
      Location:481 → 581
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:2 → 391
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:390 → 504
      Kinesin_assoc; Kinesin-associated
      cl14643
      Location:4381 → 4585
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120459567..120562371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162495.1 → XP_036018388.1  stAR-related lipid transfer protein 9 isoform X1

      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Conserved Domains (4) summary
      cd00060
      Location:481 → 594
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:2 → 391
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:390 → 504
      Kinesin_assoc; Kinesin-associated
      cl14643
      Location:4394 → 4598
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_006500511.4 → XP_006500574.1  stAR-related lipid transfer protein 9 isoform X3

      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Conserved Domains (2) summary
      cd00060
      Location:7 → 87
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl14643
      Location:3887 → 4091
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. XM_036162496.1 → XP_036018389.1  stAR-related lipid transfer protein 9 isoform X2

      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Conserved Domains (4) summary
      cd00060
      Location:125 → 238
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam16183
      Location:34 → 148
      Kinesin_assoc; Kinesin-associated
      cl14643
      Location:4038 → 4242
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
      cl22853
      Location:1 → 35
      Motor_domain; Myosin and Kinesin motor domain

    4. XM_006500512.5 → XP_006500575.1  stAR-related lipid transfer protein 9 isoform X5

      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Conserved Domains (2) summary
      pfam13868
      Location:3536 → 3584
      TPH; Trichohyalin-plectin-homology domain
      cl14643
      Location:3707 → 3911
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    5. XM_030251969.2 → XP_030107829.1  stAR-related lipid transfer protein 9 isoform X5

      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Conserved Domains (2) summary
      pfam13868
      Location:3536 → 3584
      TPH; Trichohyalin-plectin-homology domain
      cl14643
      Location:3707 → 3911
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    6. XM_036162497.1 → XP_036018390.1  stAR-related lipid transfer protein 9 isoform X4

      UniProtKB/Swiss-Prot
      O35058, Q80TF6, Q8C121, Q8CFL0
      Conserved Domains (1) summary
      cl14643
      Location:3755 → 3959
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RNA

    1. XR_004940707.1 RNA Sequence

    2. XR_004940706.1 RNA Sequence

    3. XR_004940708.1 RNA Sequence

      Related
      ENSMUST00000140843.9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010621.1: Suppressed sequence

      Description
      NM_010621.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TF6.2 GenPept UniProtKB/Swiss-Prot:Q80TF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials