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    CG3770 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3770provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035085
    Locus tag
    Dmel_CG3770
    See related
    AllianceGenome:FB:FBgn0035085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT12588; Dmel\CG3770
    Summary
    Predicted to be located in septate junction. Predicted to be active in membrane. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3770 in Genome Data Viewer
    Location:
    60E8-60E8; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24945139..24946636)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20832662..20834159)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Troponin C-akin-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Nelson KS, et al. Genetics, 2010 Jul. PMID 20407131, Free PMC Article
    2. Organization and function of the blood-brain barrier in Drosophila. Stork T, et al. J Neurosci, 2008 Jan 16. PMID 18199760, Free PMC Article
    3. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. Wu VM, et al. J Cell Biol, 2004 Jan 19. PMID 14734539, Free PMC Article
    4. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Shulman JM, et al. Am J Hum Genet, 2011 Feb 11. PMID 21295279, Free PMC Article
    5. A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration. Kotian N, et al. G3 (Bethesda), 2022 Jan 4. PMID 34849760, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    NOT involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septate junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3770-PA
    CG3770-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24945139..24946636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138141.3 → NP_611985.2  uncharacterized protein Dmel_CG3770, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611985.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SW9, Q9W0X9
      Related
      FBpp0072300
      Conserved Domains (1) summary
      pfam10242
      Location:10 → 195
      L_HGMIC_fpl; Lipoma HMGIC fusion partner-like protein

    2. NM_001299935.1 → NP_001286864.1  uncharacterized protein Dmel_CG3770, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SW9, Q9W0X9
      Conserved Domains (1) summary
      pfam10242
      Location:10 → 195
      L_HGMIC_fpl; Lipoma HMGIC fusion partner-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SW9 Q95SW9
    Q9W0X9 Q9W0X9

    Gene LinkOut

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