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    PIG-O Phosphatidylinositol glycan anchor biosynthesis class O [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Oprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Oprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034346
    Locus tag
    Dmel_CG12263
    See related
    AllianceGenome:FB:FBgn0034346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.205; CG12263; Dmel\CG12263; DmPIG-O; PIGO
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-O in Genome Data Viewer
    Location:
    55C9-55C9; 2-85 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18426421..18430333)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14313926..14317838)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene immune deficiency Neighboring gene Dodeca-satellite-binding protein 1 Neighboring gene uncharacterized protein Neighboring gene TRPL translocation defect 14 Neighboring gene scruin like at the midline Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila. Yamamoto-Hino M, et al. J Cell Sci, 2018 Oct 26. PMID 30266758, Free PMC Article
    2. Computational identification of Ftz/Ftz-F1 downstream target genes. Bowler T, et al. Dev Biol, 2006 Nov 1. PMID 16996052
    3. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    4. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    5. Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. Peng D, et al. Nat Commun, 2024 May 1. PMID 38693116, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class O
    Names
    CG12263-PA
    PIG-O-PA
    NP_611332.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18426421..18430333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137488.3 → NP_611332.1  phosphatidylinositol glycan anchor biosynthesis class O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB84, Q7YU86
      Related
      FBpp0085870
      Conserved Domains (1) summary
      cd16023
      Location:74 → 349
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB84 A1ZB84
    Q7YU86 Q7YU86

    Gene LinkOut

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