U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vha100-2 Vacuolar H[+] ATPase 100kD subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42216, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Vha100-2provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 100kD subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0028670
    Locus tag
    Dmel_CG18617
    See related
    AllianceGenome:FB:FBgn0028670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.296; BcDNA:LD21735; CG18617; CG7679; Dmel\CG18617; V100-2; vha100-2
    Summary
    Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult copper cell; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; and renal tubular acidosis. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1) and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Vha100-2 in Genome Data Viewer
    Location:
    91A5-91A5; 3-63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18390323..18399169, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14216045..14224891, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 100kD subunit 4 Neighboring gene corona Neighboring gene Vesicle transport through interaction with t-SNAREs 1b Neighboring gene WD repeat domain 37 Neighboring gene kokopelli

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Fan QX, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572941
    2. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Zoncu R, et al. Science, 2011 Nov 4. PMID 22053050, Free PMC Article
    3. Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death. Mondragon AA, et al. Cell Rep, 2019 Apr 2. PMID 30943394, Free PMC Article
    4. Investigation of Isoform Specific Functions of the V-ATPase a Subunit During Drosophila Wing Development. Mo D, et al. Front Genet, 2020. PMID 32754202, Free PMC Article
    5. Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop. Wissel S, et al. J Cell Biol, 2018 Sep 3. PMID 29959232, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    vacuolar H[+] ATPase 100kD subunit 2
    Names
    CG18617-PA
    CG18617-PB
    Vha100-2-PA
    Vha100-2-PB
    vacuolar H + ATPase subunit 100-2
    vacuolar H[+] ATPase subunit 100-2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18390323..18399169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142465.2 → NP_650722.1  vacuolar H[+] ATPase 100kD subunit 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE75, Q9VE76, Q9XZ27
      Related
      FBpp0083071
      Conserved Domains (2) summary
      COG1269
      Location:35 → 825
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 824
      V_ATPase_I; V-type ATPase 116kDa subunit family

    2. NM_169810.2 → NP_732337.1  vacuolar H[+] ATPase 100kD subunit 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732337.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE75, Q9VE76, Q9XZ27
      Related
      FBpp0083072
      Conserved Domains (2) summary
      COG1269
      Location:35 → 825
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 824
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE75 Q9VE75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous