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    CCT4 Chaperonin containing TCP1 subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34674, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CCT4provided by FlyBase
    Official Full Name
    Chaperonin containing TCP1 subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032444
    Locus tag
    Dmel_CG5525
    See related
    AllianceGenome:FB:FBgn0032444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cct4; Cct4; CG5525; Dmel\CG5525; Q9VK69_DROME; TCP-1; Tcp-1delta; Tcp1-delta; TCP1-delta
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Used to study intrinsic cardiomyopathy. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCT4 in Genome Data Viewer
    Location:
    33F3-33F3; 2-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12690336..12692934, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12690336..12692934, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nubbin Neighboring gene RNA and export factor binding protein 2 Neighboring gene POU domain protein 2 Neighboring gene Neprilysin-like 7 Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 43 Neighboring gene Protein interacting with C kinase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article
    2. Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration. Ogneva IV, et al. Int J Mol Sci, 2020 Aug 20. PMID 32825268, Free PMC Article
    3. Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Plimpton RL, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675501, Free PMC Article
    4. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article
    5. CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease. Lottes EN, et al. Cells, 2024 Jun 13. PMID 38920658, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    chaperonin containing TCP1 subunit 4
    Names
    CCT4-PA
    CG5525-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12690336..12692934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135735.3 → NP_609579.1  chaperonin containing TCP1 subunit 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK69
      Related
      FBpp0079992
      Conserved Domains (2) summary
      cd03338
      Location:18 → 531
      TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:37 → 529
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK69 Q9VK69

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