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    Dsk Drosulfakinin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45845, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dskprovided by FlyBase
    Official Full Name
    Drosulfakininprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000500
    Locus tag
    Dmel_CG18090
    See related
    AllianceGenome:FB:FBgn0000500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH46857; CCK; CG18090; Dmel\CG18090; Drm-SK; Drm-SK-0; Drm-SK-1; Drm-SK-2; DrmSK-I; DrmSK-II; Drosulfakinin 1; Drosulfakinin 2; dsk; DSK; DSK I; DSK II; DSK-0; DSK-1; DSK-2; DSK-I; SK; SK-0
    Summary
    Enables neuropeptide hormone activity and neuropeptide receptor binding activity. Involved in several processes, including adult feeding behavior; adult locomotory behavior; and neuropeptide signaling pathway. Acts upstream of with a negative effect on inter-male aggressive behavior. Predicted to be located in extracellular space. Is expressed in several structures, including Drosulfakinin neurons; larval central nervous system; neurosecretory cell of pars intercerebralis; protocerebrum; and superior neuropils. Used to study obesity. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Dsk in Genome Data Viewer
    Location:
    81F6-81F6; 3-47.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4189692..4190260, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15414..15982, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46431 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene beta-Mannosidase Neighboring gene uncharacterized protein Neighboring gene auxilin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The neuropeptide drosulfakinin enhances choosiness and protects males from the aging effects of social perception. Fedina TY, et al. Proc Natl Acad Sci U S A, 2023 Dec 19. PMID 38079545, Free PMC Article
    2. Identification and characterization of a Drosophila homologue to the vertebrate neuropeptide cholecystokinin. Nichols R, et al. J Biol Chem, 1988 Sep 5. PMID 2842322
    3. PCR amplification using deoxyinosine to replace an entire codon and at ambiguous positions. Liu H, et al. Biotechniques, 1994 Jan. PMID 8136131
    4. Spatial and temporal immunocytochemical analysis of drosulfakinin (Dsk) gene products in the Drosophila melanogaster central nervous system. Nichols R, et al. Cell Tissue Res, 1996 Jan. PMID 8581950
    5. The first nonsulfated sulfakinin activity reported suggests nsDSK acts in gut biology. Nichols R. Peptides, 2007 Apr. PMID 17292511

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosulfakinin (DSKM) and fruitless (fruM)-expressing neurons inhibit male courtship.
      Title: Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila.
    2. This study reports nsDSK II signals through DSK-R2 to influence gut motility and locomotion, identifying a novel role for the N-terminal extension in sulfakinin biology and receptor activation; it also led to the discovery of nsDSK II structural analogs that act as super and protean agonists
      Title: The 5-amino acid N-terminal extension of non-sulfated drosulfakinin II is a unique target to generate novel agonists.
    3. dDsk2 prevents dUbp8/Nonstop-dependent H2Bub1 deubiquitylation at promoters of dHP1c complex target genes and regulates RNA polymerase II pausing.
      Title: dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.
    4. Peptide and genomic conservation, activity, and spatial and temporal distribution support the conclusion that DSK 0 plays diverse biological roles in drosopholids including regulating gut muscle contraction.
      Title: The drosulfakinin 0 (DSK 0) peptide encoded in the conserved Dsk gene affects adult Drosophila melanogaster crop contractions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    drosulfakinin
    Names
    CG18090-PA
    Dsk-PA
    cholecystokinin-like
    drosophila sulfakinin
    drososulfakinin
    drosulfakinins
    sulfakinin
    sulfakinin-0

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4189692..4190260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080106.3 → NP_524845.2  drosulfakinin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524845.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2ZB94, P09040, Q8MYU9, Q9VMY4
      UniProtKB/TrEMBL
      A0A5P9K655
      Related
      FBpp0078628
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09040.2 P09040

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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