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    Xpac Xeroderma pigmentosum group A-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xpacprovided by FlyBase
    Official Full Name
    Xeroderma pigmentosum group A-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004832
    Locus tag
    Dmel_CG6358
    See related
    AllianceGenome:FB:FBgn0004832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6358; DhR14; DhXPA; Dmel\CG6358; dmXPA; DmXPA; dxpa; Dxpa; EG:EG0007.8; Xpa; XPA; XPAC; XPA_DROME
    Summary
    Predicted to enable damaged DNA binding activity. Involved in nucleotide-excision repair. Located in nucleus. Is expressed in several structures, including adult central nervous system; lamina; larval ventral nerve cord; muscle cell; and retina. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Xpac in Genome Data Viewer
    Location:
    4A5-4A5; 1-6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4102955..4104197, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3996988..3998230, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cap methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene brainiac Neighboring gene ciboulot

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-species investigation into the requirement of XPA for nucleotide excision repair. Kose C, et al. Nucleic Acids Res, 2024 Jan 25. PMID 37994737, Free PMC Article
    2. Expression and functional analyses of the Dxpa gene, the Drosophila homolog of the human excision repair gene XPA. Shimamoto T, et al. J Biol Chem, 1995 Sep 22. PMID 7673233
    3. Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster. Shimamoto T, et al. Biochem Biophys Res Commun, 1991 Dec 31. PMID 1764072
    4. Ciboulot regulates actin assembly during Drosophila brain metamorphosis. Boquet I, et al. Cell, 2000 Sep 15. PMID 11030623
    5. Cellular responses to DNA damage in Drosophila melanogaster. Dusenbery RL, et al. Mutat Res, 1996 Dec 2. PMID 8960126

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UV-damage excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA damage recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    xeroderma pigmentosum group A-like
    Names
    CG6358-PA
    Xpac-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4102955..4104197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057518.4 → NP_476866.1  xeroderma pigmentosum group A-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28518, Q24594, Q9V3V8
      UniProtKB/TrEMBL
      D3PFI1, H0RNH2
      Related
      FBpp0070638
      Conserved Domains (3) summary
      TIGR00598
      Location:126 → 296
      rad14; DNA repair protein
      pfam01286
      Location:125 → 154
      XPA_N; XPA protein N-terminal
      pfam05181
      Location:156 → 207
      XPA_C; XPA protein C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28518.3 P28518

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