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    lbe ladybird early [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42542, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lbeprovided by FlyBase
    Official Full Name
    ladybird earlyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011278
    Locus tag
    Dmel_CG6545
    See related
    AllianceGenome:FB:FBgn0011278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6545; Dmel\CG6545; Hox11-D125; lb; Lb; Lbe; NK?
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including imaginal disc morphogenesis; myoblast fusion; and regulation of myoblast fusion. Located in nucleus. Is expressed in several structures, including anal pad primordium; cuboidal/columnar epithelium; segment; somatic muscle cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to several human genes including LBX1 (ladybird homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lbe in Genome Data Viewer
    Location:
    93E1-93E1; 3-72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21441577..21446537, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17267299..17272259, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ladybird late Neighboring gene long non-coding RNA:CR44089 Neighboring gene long non-coding RNA:CR43453 Neighboring gene Fanconi anemia group M helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A distinct class of homeodomain proteins is encoded by two sequentially expressed Drosophila genes from the 93D/E cluster. Jagla K, et al. Nucleic Acids Res, 1994 Apr 11. PMID 7909370, Free PMC Article
    2. Complex interplay of evolutionary forces in the ladybird homeobox genes of Drosophila melanogaster. Balakirev ES, et al. PLoS One, 2011. PMID 21799919, Free PMC Article
    3. Coordinated Development of Muscles and Tendon-Like Structures: Early Interactions in the Drosophila Leg. Soler C, et al. Front Physiol, 2016. PMID 26869938, Free PMC Article
    4. Impact of Ultrabithorax alternative splicing on Drosophila embryonic nervous system development. Geyer A, et al. Mech Dev, 2015 Nov. PMID 26299253
    5. Plasticity within the lateral somatic mesoderm of Drosophila embryos. Jagla T, et al. Int J Dev Biol, 1999 Sep. PMID 10610031

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. here we examine the interactions between Msk and the Wg pathway in regulation of the AMP pool size. We find that a myoblast-specific reduction of Msk results in the absence of Vg expression and a complete loss of the Wg pathway readout beta-catenin/Armadillo (Arm). Moreover, msk RNA interference knockdown abolishes expression of the Wg target Ladybird (Lbe) in leg disc myoblasts.
      Title: Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors.
    2. Lbe role in the neuronal cell fate specification
      Title: Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade.
    3. evolution of lbe and lbl
      Title: Complex interplay of evolutionary forces in the ladybird homeobox genes of Drosophila melanogaster.
    4. Data show that the homeobox genes ladybird early and ladybird late are expressed in subsets of cells deriving from neuroblasts NB 5-3 and NB 5-6 and are essential for their correct development.
      Title: The ladybird homeobox genes are essential for the specification of a subpopulation of neural cells.
    5. in developing Drosophila cardiac progenitor cells, the Eve precursors next to the Hh stripe are distinguished from more distant Lbe precursors by locally augmenting Ras signaling via elevating rho transcripts
      Title: Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in genital disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myoblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somatic muscle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ladybird early
    Names
    CG6545-PA
    Ladybird-early
    lady-bird-early
    ladybird
    lbe-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21441577..21446537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079711.3 → NP_524435.2  ladybird early [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524435.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91625, Q24358, Q7KS77, Q9VDA1
      Related
      FBpp0083490
      Conserved Domains (1) summary
      pfam00046
      Location:356 → 410
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61676 Q61676
    Q7JMT6 Q7JMT6
    Q7KS77 Q7KS77
    Q9VDA1 Q9VDA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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