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    caps capricious [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    capsprovided by FlyBase
    Official Full Name
    capriciousprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023095
    Locus tag
    Dmel_CG11282
    See related
    AllianceGenome:FB:FBgn0023095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD07388; Caps; CAPS; CG11282; CT31495; Dmel\CG11282; l(3)02937; l(3)rM632
    Summary
    Involved in several processes, including axon guidance; branch fusion, open tracheal system; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in muscle cell projection. Colocalizes with cytoneme. Is expressed in several structures, including antennal lobe glomerulus; embryonic/larval motor neurons; gut section; larval somatic muscle cell; and organism subdivision. Orthologous to human LRRC4C (leucine rich repeat containing 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See caps in Genome Data Viewer
    Location:
    70A3-70A4; 3-40 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13228692..13279642)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13221792..13272742)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43914 Neighboring gene long non-coding RNA:CR45098 Neighboring gene transfer RNA:Aspartic acid-GTC 1-10 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43146 Neighboring gene long non-coding RNA:CR43913

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila synapse formation: regulation by transmembrane protein with Leu-rich repeats, CAPRICIOUS. Shishido E, et al. Science, 1998 Jun 26. PMID 9641918
    2. Axon guidance of Drosophila SNb motoneurons depends on the cooperative action of muscular Krüppel and neuronal capricious activities. Abrell S, et al. Mech Dev, 2001 Nov. PMID 11677048
    3. Functional dissection of drosophila capricious: its novel roles in neuronal pathfinding and selective synapse formation. Taniguchi H, et al. J Neurobiol, 2000 Jan. PMID 10623905
    4. The Selector Gene apterous and Notch Are Required to Locally Increase Mechanical Cell Bond Tension at the Drosophila Dorsoventral Compartment Boundary. Michel M, et al. PLoS One, 2016. PMID 27552097, Free PMC Article
    5. Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan. Milán M, et al. Dev Dyn, 2005 Jul. PMID 15830355

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caps and tartan proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation
      Title: Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map.
    2. In caps mutants, or in double mutants lacking both CAPS and the closely related protein Tartan, we observed fewer contacts between myopodia of M12 and the presynaptic growth cones during the process of initial neuromuscular interaction.
      Title: Target recognition at the tips of postsynaptic filopodia: accumulation and function of Capricious.
    3. Capricious and Tartan contribute to the adhesive properties of the cells in the morphogenetic furrow and that this regulated adhesion participates in the control of spacing ommatidial clusters
      Title: Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan.
    4. extracellular domains of Capricious and Tartan may work as ligands of an unknown dorsal cell surface protein, and required to transduce a signal necessary for the establishment of the DV boundary
      Title: Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in larval salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with cytoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in muscle cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    capricious
    Names
    CG11282-PA
    CG11282-PB
    CG11282-PD
    CG11282-PE
    caps-PA
    caps-PB
    caps-PD
    caps-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13228692..13279642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079332.4 → NP_524056.3  capricious, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524056.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96671, Q9VU53
      Related
      FBpp0075570
      Conserved Domains (4) summary
      smart00082
      Location:395 → 445
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:147 → 397
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 201
      LRR_8; Leucine rich repeat

    2. NM_001043139.4 → NP_001036604.2  capricious, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036604.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8F0
      Conserved Domains (4) summary
      smart00082
      Location:395 → 445
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:147 → 397
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 201
      LRR_8; Leucine rich repeat

    3. NM_001316462.1 → NP_001303391.1  capricious, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WP14
      Conserved Domains (4) summary
      smart00082
      Location:395 → 445
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:147 → 397
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 201
      LRR_8; Leucine rich repeat

    4. NM_168540.3 → NP_729880.2  capricious, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729880.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96671, Q9VU53
      Related
      FBpp0075571
      Conserved Domains (4) summary
      smart00082
      Location:395 → 445
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:147 → 397
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 201
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WP14 A0A0S0WP14
    O96671 O96671
    Q0E8F0 Q0E8F0
    Q8IH19 Q8IH19
    Q9VU53 Q9VU53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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