Seipin seipin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Seipinprovided by FlyBase
Official Full Name: seipinprovided by FlyBase
Primary source: FLYBASE:FBgn0040336
Locus tag: Dmel_CG9904
See related: AllianceGenome:FB:FBgn0040336
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9904; Dmel\CG9904; dmSeipin; dSeipin; EG:BACR7C10.1; seipin
Summary: Enables channel activator activity. Involved in several processes, including glycerolipid metabolic process; lipid droplet formation; and regulation of lipid metabolic process. Located in endoplasmic reticulum and lipid droplet. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval salivary gland; gut section; and larval brain. Used to study congenital generalized lipodystrophy. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 13; congenital generalized lipodystrophy type 2; hereditary spastic paraplegia; hereditary spastic paraplegia 17; and lipodystrophy. Orthologous to human BSCL2 (BSCL2 lipid droplet biogenesis associated, seipin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3A7-3A8; 1-1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2619799..2622140)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2513832..2516173)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results reveal that Seipin promotes adipose tissue lipid storage via calcium-dependent mitochondrial metabolism.
Title: Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism.
functional testing in cells suggest a model in which seipin oligomers initially detect forming LDs in the ER via HHs and subsequently act as membrane anchors to enable lipid transfer and LD growth.
Title: Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.
dSeipin may participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis to prevent ectopic lipid droplet formation.
Title: Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables channel activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: seipin

Names: CG9904-PA; Seipin-PA; dSeipin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2619799..2622140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130656.4 → NP_570012.1 seipin [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_570012.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3X4

Related

FBpp0070426

Conserved Domains (1) summary

pfam06775
Location:63 → 262

Seipin; Putative adipose-regulatory protein (Seipin)