Tre1 Trapped in endoderm 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tre1provided by FlyBase
Official Full Name: Trapped in endoderm 1provided by FlyBase
Primary source: FLYBASE:FBgn0046687
Locus tag: Dmel_CG3171
See related: AllianceGenome:FB:FBgn0046687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.16; anon-WO0170980.17; anon-WO0170981.1; BEST:LD12308; CG 3171; CG3171; Dmel\CG3171; LD12308; sctt; Tre; TRE; tre-1; Tre-1; tre1
Summary: Predicted to enable G protein-coupled receptor activity. Involved in germ cell development and germ cell migration. Located in cell cortex. Is expressed in several structures, including anlage in statu nascendi; circulatory system primordium; embryonic/larval midgut primordium; head epidermis primordium; and larval midgut enterocyte. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5A11-5A12; 1-12 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5673830..5679977, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5567863..5574010, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells.
Title: Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P(2) to direct migration of Drosophila embryonic germ cells.
The authors uncovered a novel role for Rho-like signaling through the G protein-coupled receptor Tre1, a gene previously implicated in the trans-epithelial migration of germ cells.
Title: Drosophila immune cells extravasate from vessels to wounds using Tre1 GPCR and Rho signaling.
Bifurcation of the Tre1 G protein-coupled receptor signaling response via G protein-dependent and independent branches enables distinct spatiotemporal regulation of germ cell migration.
Title: Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR.
feminizing the Tre1-expressing neurons in male flies leads to rapid courtship initiation, a phenotype that leads to increased reproductive success; Tre1 is expressed in a sexually dimorphic pattern in olfactory sensory neurons and the central nervous system
Title: A Novel Gene Controlling the Timing of Courtship Initiation in Drosophila melanogaster.
role of the arginine of the NRY motif in Tre1 was investigated; results suggest that a salt bridge may form between this critical arginine and an aspartic acid in transmembrane alpha-helix (TM6)in Tre1
Title: Molecular dynamics simulations on the Tre1 G protein-coupled receptor: exploring the role of the arginine of the NRY motif in Tre1 structure.
The scattershot allele results in an in-frame deletion of 8 amino acids at the junction of the third transmembrane domain and the second intracellular loop of Tre1 that dramatically impairs the function of this GPCR in germ cell migration.
Title: An evolutionarily conserved arginine is essential for Tre1 G protein-coupled receptor function during germ cell migration in Drosophila melanogaster.
plays an important role in regulation of germ cell migration, polarity , cell adhesion, and cadherin binding. (review)
Title: [New insights into cell migration from Drosophila germ cell migration].
Down-regulation of E-cadherin causes germ cell dispersal but is not sufficient for transepithelial migration in the absence of Tre1, suggesting a new mechanism for Tre1 GPCR function that links cell polarity, modulation of cell adhesion, and invasion.
Title: Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin.
Tre1 is a G protein-coupled receptor that directs transepithelial migration of Drosophila germ cells
Title: Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.
single P-element insertions in the intergenic region between Gr5a and Tre1 exert complex pleiotropic effects on fitness traits, including selective nutrient intake, life span, and resistance to starvation and heat stress
Title: Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in ectopic germ cell programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: trapped in endoderm 1

Names: CG3171-PA; CG3171-PB; CG3171-PC; G protein coupled receptor; Tre1-PA; Tre1-PB; Tre1-PC; scattershot; trapped in endoderm-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5673830..5679977 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080053.4 → NP_524792.1 trapped in endoderm 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524792.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95NV3, Q95NV9, Q9NDM2, Q9NKZ6, Q9W498

UniProtKB/TrEMBL

D2CFN9, M9NGQ9

Related

FBpp0070813

Conserved Domains (1) summary

pfam00001
Location:52 → 323

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001297972.1 → NP_001284901.1 trapped in endoderm 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284901.1

Status: REVIEWED

UniProtKB/TrEMBL

D2CFN9, X2JIG6

Conserved Domains (1) summary

pfam00001
Location:52 → 323

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001258605.1 → NP_001245534.1 trapped in endoderm 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245534.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95NV3, Q95NV9, Q9NDM2, Q9NKZ6, Q9W498

UniProtKB/TrEMBL

D2CFN9, M9NGQ9

Conserved Domains (1) summary

pfam00001
Location:52 → 323

7tm_1; 7 transmembrane receptor (rhodopsin family)