Smr Smrter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Smrprovided by FlyBase
Official Full Name: Smrterprovided by FlyBase
Primary source: FLYBASE:FBgn0265523
Locus tag: Dmel_CG4013
See related: AllianceGenome:FB:FBgn0265523
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.73; CG12719; CG4013; Dmel\CG4013; E52; l(1)G0060; l(1)G0361; lincRNA.983; smr; SMR; SMRTER
Summary: Enables chromatin binding activity. Involved in several processes, including follicle cell of egg chamber development; negative regulation of transcription by RNA polymerase II; and wing disc development. Located in polytene chromosome. Part of transcription repressor complex. Is expressed in several structures, including adult brain cell body rind; adult mushroom body; adult optic lobe; eye photoreceptor cell; and spermatozoon. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to several human genes including NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11B10-11B14; 1-39 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12684203..12742618, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12578236..12636651, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.
Title: The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.
An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.
Title: An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2078 (e-PCR)
- UniSTS:515482

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	NAS Non-traceable Author Statement more info	PubMed
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: smrter

Names: CG4013-PD; CG4013-PE; CG4013-PF; CG4013-PG; SANT domain protein; SMRT-related ecdysone receptor interacting factor; SMRT-related ecdysone receptor-interacting factor; Smr-PD; Smr-PE; Smr-PF; Smr-PG; lethal (1) G0060; silencing mediator of retinoid and thyroid hormone receptors-related ecdysone receptor-interacting factor; smarter

NP_001259491.1

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12684203..12742618 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167334.2 → NP_727634.2 smrter, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727634.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U4I2, Q9VYK0

Conserved Domains (3) summary

cd00167
Location:1003 → 1042

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam13868
Location:719 → 1000

TPH; Trichohyalin-plectin-homology domain

pfam15784
Location:704 → 792

GPS2_interact; G-protein pathway suppressor 2-interacting domain
NM_001272562.1 → NP_001259491.1 smrter, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259491.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGZ8, Q9U4I2

Conserved Domains (3) summary

cd00167
Location:1009 → 1048

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam13868
Location:725 → 1006

TPH; Trichohyalin-plectin-homology domain

pfam15784
Location:710 → 798

GPS2_interact; G-protein pathway suppressor 2-interacting domain
NM_080536.4 → NP_536797.3 smrter, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536797.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9U4I2, Q9VYK0

Conserved Domains (3) summary

cd00167
Location:1003 → 1042

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam13868
Location:719 → 1000

TPH; Trichohyalin-plectin-homology domain

pfam15784
Location:704 → 792

GPS2_interact; G-protein pathway suppressor 2-interacting domain
NM_167335.2 → NP_727635.2 smrter, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727635.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U4I2, Q9VYK0

Conserved Domains (3) summary

cd00167
Location:1003 → 1042

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam13868
Location:719 → 1000

TPH; Trichohyalin-plectin-homology domain

pfam15784
Location:704 → 792

GPS2_interact; G-protein pathway suppressor 2-interacting domain