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    beta3GalTII beta-1,3-Galactosyltransferase II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    beta3GalTIIprovided by FlyBase
    Official Full Name
    beta-1,3-Galactosyltransferase IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033315
    Locus tag
    Dmel_CG8734
    See related
    AllianceGenome:FB:FBgn0033315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8734; dbeta3GalTII; dGAGbeta3GalTII; Dmel\CG8734; GalTII
    Summary
    Enables galactosylxylosylprotein 3-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Orthologous to human B3GALT6 (beta-1,3-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See beta3GalTII in Genome Data Viewer
    Location:
    44D5-44D5; 2-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8626181..8627611, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4513686..4515116, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Calcium-independent receptor for alpha-latrotoxin Neighboring gene Vacuolar protein sorting 25 Neighboring gene Gle1 RNA export mediator Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. Schwientek T, et al. J Biol Chem, 2002 Sep 6. PMID 12130651
    2. Functional analysis of proteoglycan galactosyltransferase II RNA interference mutant flies. Ueyama M, et al. J Biol Chem, 2008 Mar 7. PMID 18165227
    3. A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. Bornemann DJ, et al. Development, 2008 Mar. PMID 18256192, Free PMC Article
    4. Glycosylation of proteins in plants and invertebrates. Wilson IB. Curr Opin Struct Biol, 2002 Oct. PMID 12464307
    5. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-Galactosyltransferase II
    Names
    CG8734-PA
    beta3GalTII-PA
    galactosyltransferase II
    NP_610399.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8626181..8627611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136555.3 → NP_610399.1  beta-1,3-Galactosyltransferase II [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7G9, Q4V698
      Related
      FBpp0087807
      Conserved Domains (1) summary
      cl21608
      Location:125 → 319
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7G9 A1Z7G9

    Gene LinkOut

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