Ire1 Inositol-requiring enzyme-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ire1provided by FlyBase
Official Full Name: Inositol-requiring enzyme-1provided by FlyBase
Primary source: FLYBASE:FBgn0261984
Locus tag: Dmel_CG4583
See related: AllianceGenome:FB:FBgn0261984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4583; dire-1; dIRE1; Dmel\CG4583; ERN1; Ire; ire-1; Ire-1; IRE-like; ire1; IRE1; Ire1alpha; IRE1alpha
Summary: Enables RNA endonuclease activity. Involved in several processes, including IRE1-mediated unfolded protein response; regulation of gene expression; and rhabdomere morphogenesis. Predicted to be part of IRE1-TRAF2-ASK1 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 92B3-92B3; 3-67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19853908..19861291, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15679630..15687013, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease.
Title: RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease.
The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila.
Title: The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila.
Differential Ire1 determines loser cell fate in tumor-suppressive cell competition.
Title: Differential Ire1 determines loser cell fate in tumor-suppressive cell competition.
PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy.
Title: PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy.
Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.
Title: Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.
The role of Ire1 in Drosophila eye pigmentation revealed by an RNase dead allele.
Title: The role of Ire1 in Drosophila eye pigmentation revealed by an RNase dead allele.
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.
Title: IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.
Genotoxic stress triggers the activation of IRE1alpha-dependent RNA decay to modulate the DNA damage response.
Title: Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.
XBP1-independent IRE1 RNase activity, while challenging the importance of RNase-independent effector mechanisms of Drosophila IRE1 function.
Title: The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.
the IRE1/XBP1 endoplasmic reticulum (ER) stress signaling module mediates metabolic adaptation upon dietary restriction in flies.
Title: Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1679 (e-PCR)
- UniSTS:30482

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in IRE1-mediated unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in IRE1-mediated unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in IRE1-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in IRE1-mediated unfolded protein response	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in compound eye photoreceptor fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in rhabdomere morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of IRE1-TRAF2-ASK1 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Inositol-requiring enzyme-1

Names: CG4583-PB; Ire; Ire1-PB; inositol required 1; ire-1

NP_001097839.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

19853908..19861291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104369.2 → NP_001097839.1 Inositol-requiring enzyme-1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097839.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR46

Conserved Domains (4) summary

cd09769
Location:53 → 321

Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1

cd10422
Location:817 → 941

RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1

smart00220
Location:552 → 812

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13982
Location:545 → 813

STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1