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    CG4393 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42764, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG4393provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039075
    Locus tag
    Dmel_CG4393
    See related
    AllianceGenome:FB:FBgn0039075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ANKS1A; Dmel\CG4393
    Summary
    Predicted to be active in cytosol. Is expressed in spermatozoon. Orthologous to several human genes including ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4393 in Genome Data Viewer
    Location:
    94F1-94F1; 3-79 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23375928..23384777, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19201650..19210499, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43387

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. Weng YL, et al. J Neurosci, 2011 Mar 23. PMID 21430143, Free PMC Article
    2. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    3. Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Hoi CS, et al. Genetics, 2016 Jul. PMID 27194748, Free PMC Article
    4. Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Kankel MW, et al. Genetics, 2020 Jul. PMID 32345615, Free PMC Article
    5. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4393-PB
    CG4393-PC
    CG4393-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23375928..23384777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300555.1 → NP_001287484.1  uncharacterized protein Dmel_CG4393, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287484.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EC88, Q9VCM6
      Conserved Domains (7) summary
      cd09500
      Location:1005 → 1069
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:1009 → 1075
      SAM; Sterile alpha motif
      cd00204
      Location:43 → 171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:1161 → 1305
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:53 → 148
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:224 → 276
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:49 → 79
      ANK; ANK repeat [structural motif]

    2. NM_142886.2 → NP_651143.2  uncharacterized protein Dmel_CG4393, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651143.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EC88, Q9VCM6
      Conserved Domains (7) summary
      cd09500
      Location:1005 → 1069
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:1009 → 1075
      SAM; Sterile alpha motif
      cd00204
      Location:43 → 171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:1161 → 1305
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:53 → 148
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:224 → 276
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:49 → 79
      ANK; ANK repeat [structural motif]

    3. NM_001300554.1 → NP_001287483.1  uncharacterized protein Dmel_CG4393, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EC88, Q9VCM6
      Conserved Domains (7) summary
      cd09500
      Location:1005 → 1069
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:1009 → 1075
      SAM; Sterile alpha motif
      cd00204
      Location:43 → 171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:1161 → 1305
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:53 → 148
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:224 → 276
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:49 → 79
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCM6 Q9VCM6

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