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    Bace beta-site APP-cleaving enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34182, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Baceprovided by FlyBase
    Official Full Name
    beta-site APP-cleaving enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032049
    Locus tag
    Dmel_CG13095
    See related
    AllianceGenome:FB:FBgn0032049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.142; BACE; BACE-1; CG13095; DASP2; dBace; dBACE; Dmel\CG13095
    Summary
    Enables aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in apoptotic process and proteolysis. Located in axon and neuronal cell body. Is expressed in adult brain; adult brain cell body rind; adult head; lamina; and medulla. Orthologous to several human genes including CTSE (cathepsin E); PGA3 (pepsinogen A3); and PGA4 (pepsinogen A4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bace in Genome Data Viewer
    Location:
    29D2-29D2; 2-33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8494893..8496307, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8494893..8496307, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Diuretic hormone 31 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring the efficacy of natural products in alleviating Alzheimer's disease. Deshpande P, et al. Neural Regen Res, 2019 Aug. PMID 30964049, Free PMC Article
    2. Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase. Kotani N, et al. J Biochem, 2005 Mar. PMID 15809332
    3. Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila. Bourdet I, et al. PLoS One, 2015. PMID 26274614, Free PMC Article
    4. Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila. Alattia JR, et al. FASEB J, 2011 Jul. PMID 21415381
    5. Modeling the complex pathology of Alzheimer's disease in Drosophila. Fernandez-Funez P, et al. Exp Neurol, 2015 Dec. PMID 26024860, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-site APP-cleaving enzyme
    Names
    Bace-PA
    Bace-PB
    CG13095-PA
    CG13095-PB
    NP_001285756.1
    NP_609235.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8494893..8496307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298827.1 → NP_001285756.1  beta-site APP-cleaving enzyme, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLK3
      Conserved Domains (2) summary
      pfam00026
      Location:68 → 371
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:59 → 369
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    2. NM_135391.3 → NP_609235.1  beta-site APP-cleaving enzyme, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLK3
      Related
      FBpp0079309
      Conserved Domains (2) summary
      pfam00026
      Location:68 → 371
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:59 → 369
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLK3 Q9VLK3

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