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    CG10383 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35123, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG10383provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032699
    Locus tag
    Dmel_CG10383
    See related
    AllianceGenome:FB:FBgn0032699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10383
    Summary
    Involved in determination of adult lifespan. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10383 in Genome Data Viewer
    Location:
    37A1-37A1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18690904..18695602, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18690904..18695602, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tosca Neighboring gene male-specific lethal 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Consistent effects of a major QTL for thermal resistance in field-released Drosophila melanogaster. Loeschcke V, et al. J Insect Physiol, 2011 Sep. PMID 21708160
    2. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136, Free PMC Article
    3. Combined expression patterns of QTL-linked candidate genes best predict thermotolerance in Drosophila melanogaster. Norry FM, et al. J Insect Physiol, 2009 Nov. PMID 19651134
    4. The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster. Jensen HR, et al. Insect Mol Biol, 2006 Jun. PMID 16756552
    5. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10383-PA
    CG10383-PB
    NP_001286055.1
    NP_609896.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18690904..18695602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299126.1 → NP_001286055.1  uncharacterized protein Dmel_CG10383, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ64
      Conserved Domains (1) summary
      cl21494
      Location:522 → 642
      Abhydrolase; alpha/beta hydrolases

    2. NM_136052.3 → NP_609896.1  uncharacterized protein Dmel_CG10383, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ64
      Related
      FBpp0088571
      Conserved Domains (1) summary
      cl21494
      Location:522 → 642
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961H4 Q961H4
    Q9VJ64 Q9VJ64

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