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    Rpt6 Regulatory particle triple-A ATPase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33105, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rpt6provided by FlyBase
    Official Full Name
    Regulatory particle triple-A ATPase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0020369
    Locus tag
    Dmel_CG1489
    See related
    AllianceGenome:FB:FBgn0020369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1489; CG1489; Dmel\CG1489; Dm_Rpt6a; dRpt6; Dug; DUG; p42C; pros45; Pros45; PRS8_DROME; S8; sug-1; sug1; Ug
    Summary
    Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome regulatory particle, base subcomplex. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpt6 in Genome Data Viewer
    Location:
    19F4-19F4; 1-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21316052..21317663)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21187079..21188690)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene transfer RNA:Tyrosine-GTA 1-1 Neighboring gene transfer RNA:Tyrosine-GTA 2-1 Neighboring gene uncharacterized protein Neighboring gene SRA stem-loop interacting RNA binding protein 1 Neighboring gene anorexia Neighboring gene Dullard

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of Pros45, the Drosophila SUG1 proteasome subunit homolog. Cheng L, et al. Mol Gen Genet, 1998 Jul. PMID 9738875
    2. Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila. Uechi H, et al. Mol Cell Biol, 2018 Feb 1. PMID 29109084, Free PMC Article
    3. Correct dosage of X chromosome transcription is controlled by a nuclear pore component. Aleman JR, et al. Cell Rep, 2021 Jun 15. PMID 34133927, Free PMC Article
    4. Molecular characterization of the Rpt1/p48B ATPase subunit of the Drosophila melanogaster 26S proteasome. Szabó A, et al. Mol Genet Genomics, 2007 Jul. PMID 17429695
    5. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Ojelade SA, et al. Cell Rep, 2019 Aug 13. PMID 31412248, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle triple-A ATPase 6
    Names
    26S proteasome regulatory subunit 8
    CG1489-PA
    Pros45
    Rpt6-PA
    p42C
    proteasomal subunit 8
    NP_608447.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21316052..21317663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134603.2 → NP_608447.1  regulatory particle triple-A ATPase 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18413, O45023
      Related
      FBpp0076890
      Conserved Domains (4) summary
      COG1222
      Location:17 → 403
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:185 → 317
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam13191
      Location:152 → 205
      AAA_16; AAA ATPase domain
      cl01090
      Location:27 → 69
      SlyX; SlyX
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18413.2 O18413

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