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    BORCS5 BLOC-1 related complex subunit 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BORCS5provided by FlyBase
    Official Full Name
    BLOC-1 related complex subunit 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0030346
    Locus tag
    Dmel_CG11802
    See related
    AllianceGenome:FB:FBgn0030346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11802; Dmel\CG11802
    Summary
    Predicted to be involved in lysosome localization; organelle transport along microtubule; and positive regulation of anterograde synaptic vesicle transport. Predicted to be part of BORC complex. Predicted to be active in cytoplasmic side of lysosomal membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BORCS5 in Genome Data Viewer
    Location:
    10F2-10F2; 1-37 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11871299..11872779, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11765332..11766812, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ATP7 Neighboring gene Nardilysin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Arl8 is a general positive regulator of lysosomal fusion events. Boda A, et al. Biochim Biophys Acta Mol Cell Res, 2019 Apr. PMID 30590083
    2. Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila. Inoshita T, et al. iScience, 2022 Dec 22. PMID 36404922, Free PMC Article
    3. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anterograde synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of BORC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BLOC-1 related complex subunit 5
    Names
    BORCS5-PA
    CG11802-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11871299..11872779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132531.2 → NP_572759.1  BLOC-1 related complex subunit 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYT1
      Related
      FBpp0073437
      Conserved Domains (1) summary
      pfam10158
      Location:196 → 327
      LOH1CR12; Tumour suppressor protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYT1 Q9VYT1

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