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    swm second mitotic wave missing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swmprovided by FlyBase
    Official Full Name
    second mitotic wave missingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002044
    Locus tag
    Dmel_CG10084
    See related
    AllianceGenome:FB:FBgn0002044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10084; Dmel\CG10084; E1; EC2-10; l(2)37Dh; l(2)E1; S(rux)2B; S(Rux)2B; Swm; Swm1
    Summary
    Enables mRNA binding activity. Involved in positive regulation of RNA export from nucleus and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval garland cell; embryonic/larval optic lobe; and embryonic/larval salivary gland. Orthologous to human RBM26 (RNA binding motif protein 26) and RBM27 (RNA binding motif protein 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See swm in Genome Data Viewer
    Location:
    37E4-37E4; 2-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19493251..19497978)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19493251..19497978)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytosolic thiouridylase subunit 2 Neighboring gene Topoisomerase 3alpha Neighboring gene cysts

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. Plank JL, et al. J Biol Chem, 2005 Feb 4. PMID 15537633
    2. Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A. Dong X, et al. Genes Dev, 1997 Jan 1. PMID 9000053
    3. Identification of genes required for neural-specific glycosylation using functional genomics. Yamamoto-Hino M, et al. PLoS Genet, 2010 Dec 23. PMID 21203496, Free PMC Article
    4. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Casso DJ, et al. Genetics, 2008 Mar. PMID 18245841, Free PMC Article
    5. On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus. Brittnacher JG, et al. Genetics, 1983 Apr. PMID 17246120, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. swm is recessive lethal and is predicted to encode an evolutionarily conserved protein with RNA binding and Zn(+) finger domains.
      Title: A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    second mitotic wave missing
    Names
    CG10084-PA
    CG10084-PB
    CG10084-PC
    CG10084-PD
    lethal (2) 37Dh
    swm-PA
    swm-PB
    swm-PC
    swm-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19493251..19497978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273657.1 → NP_001260586.1  second mitotic wave missing, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDF2
      Conserved Domains (2) summary
      cd12257
      Location:561 → 634
      RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
      cd12258
      Location:921 → 992
      RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins

    2. NM_136132.5 → NP_609976.1  second mitotic wave missing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609976.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B1NLF3, B1NLF4, Q9VIV2
      Related
      FBpp0080785
      Conserved Domains (2) summary
      cd12257
      Location:560 → 633
      RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
      cd12258
      Location:920 → 991
      RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins

    3. NM_165304.2 → NP_724201.1  second mitotic wave missing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724201.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B1NLF3, B1NLF4, Q9VIV2
      Related
      FBpp0080786
      Conserved Domains (2) summary
      cd12257
      Location:560 → 633
      RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
      cd12258
      Location:920 → 991
      RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins

    4. NM_001273658.1 → NP_001260587.1  second mitotic wave missing, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDF2
      Conserved Domains (2) summary
      cd12257
      Location:561 → 634
      RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
      cd12258
      Location:921 → 992
      RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDF2 M9PDF2
    Q9VIV2.1 Q9VIV2

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