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    FLYWCH1 FLYWCH-type zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 84256, updated on 10-Dec-2024

    Summary

    Official Symbol
    FLYWCH1provided by HGNC
    Official Full Name
    FLYWCH-type zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:25404
    See related
    Ensembl:ENSG00000059122 MIM:620431; AllianceGenome:HGNC:25404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables transcription coactivator binding activity and transcription corepressor activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and pericentric heterochromatin. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 6.6), ovary (RPKM 5.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FLYWCH1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2911931..2951208)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2938537..2977878)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2961932..3001209)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene FLYWCH family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:2955125-2955625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7084 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2962376-2962565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2974631-2975496 Neighboring gene ribosomal protein L23a pseudogene 86 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:2978151-2978660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2988192-2988805 Neighboring gene uncharacterized LOC105371055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3005307-3006228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3006229-3007148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3011513-3012510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3012511-3013508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3015093-3016052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3018331-3019320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3021603-3022419 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    FLYWCH-type zinc finger-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308068.2NP_001294997.1  FLYWCH-type zinc finger-containing protein 1 isoform c

      See identical proteins and their annotated locations for NP_001294997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is longer than isoform a.
      Source sequence(s)
      AC004034, AC004234, AC004235
      Consensus CDS
      CCDS76809.1
      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
      Related
      ENSP00000253928.9, ENST00000253928.14
      Conserved Domains (3) summary
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332393
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
      pfam04500
      Location:421479
      FLYWCH; FLYWCH zinc finger domain
    2. NM_020912.2NP_065963.1  FLYWCH-type zinc finger-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
      Source sequence(s)
      AC004034, AC004234
      UniProtKB/Swiss-Prot
      Q4VC44
      Conserved Domains (3) summary
      pfam04500
      Location:272330
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:331419
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    3. NM_032296.3NP_115672.2  FLYWCH-type zinc finger-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_115672.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (a).
      Source sequence(s)
      AC004034, AC004234, AC004235
      Consensus CDS
      CCDS45390.1
      UniProtKB/Swiss-Prot
      Q4VC44
      Related
      ENSP00000399938.2, ENST00000416288.6
      Conserved Domains (3) summary
      pfam04500
      Location:272330
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:331419
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2911931..2951208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434780.1XP_047290736.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
      Conserved Domains (3) summary
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332393
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
      pfam04500
      Location:421479
      FLYWCH; FLYWCH zinc finger domain
    2. XM_047434784.1XP_047290740.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

    3. XM_047434776.1XP_047290732.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

    4. XM_011522703.3XP_011521005.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011521005.1

      Conserved Domains (3) summary
      pfam04500
      Location:273331
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332420
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    5. XM_047434779.1XP_047290735.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
      Conserved Domains (3) summary
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332393
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
      pfam04500
      Location:421479
      FLYWCH; FLYWCH zinc finger domain
    6. XM_047434783.1XP_047290739.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

    7. XM_006720962.4XP_006721025.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006721025.1

      UniProtKB/Swiss-Prot
      Q4VC44
      Conserved Domains (3) summary
      pfam04500
      Location:273331
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332420
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    8. XM_011522701.3XP_011521003.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011521003.1

      Conserved Domains (3) summary
      pfam04500
      Location:273331
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332420
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    9. XM_011522705.3XP_011521007.1  FLYWCH-type zinc finger-containing protein 1 isoform X4

      Conserved Domains (3) summary
      pfam04500
      Location:273331
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332420
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    10. XM_047434777.1XP_047290733.1  FLYWCH-type zinc finger-containing protein 1 isoform X7

    11. XM_011522704.3XP_011521006.1  FLYWCH-type zinc finger-containing protein 1 isoform X2

      Conserved Domains (3) summary
      pfam04500
      Location:272330
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:331419
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    12. XM_047434774.1XP_047290730.1  FLYWCH-type zinc finger-containing protein 1 isoform X3

    13. XM_047434785.1XP_047290741.1  FLYWCH-type zinc finger-containing protein 1 isoform X10

    14. XM_047434786.1XP_047290742.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

    15. XM_047434789.1XP_047290745.1  FLYWCH-type zinc finger-containing protein 1 isoform X14

    16. XM_011522707.3XP_011521009.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

      See identical proteins and their annotated locations for XP_011521009.1

      Conserved Domains (3) summary
      pfam04500
      Location:273331
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332420
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    17. XM_047434787.1XP_047290743.1  FLYWCH-type zinc finger-containing protein 1 isoform X12

    18. XM_047434775.1XP_047290731.1  FLYWCH-type zinc finger-containing protein 1 isoform X5

    19. XM_047434782.1XP_047290738.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

    20. XM_047434781.1XP_047290737.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
      Conserved Domains (3) summary
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332393
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
      pfam04500
      Location:421479
      FLYWCH; FLYWCH zinc finger domain
    21. XM_047434778.1XP_047290734.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
      Conserved Domains (3) summary
      pfam15423
      Location:1107
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:332393
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
      pfam04500
      Location:421479
      FLYWCH; FLYWCH zinc finger domain
    22. XM_047434788.1XP_047290744.1  FLYWCH-type zinc finger-containing protein 1 isoform X13

    23. XM_047434790.1XP_047290746.1  FLYWCH-type zinc finger-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      B3KP60
    24. XM_047434791.1XP_047290747.1  FLYWCH-type zinc finger-containing protein 1 isoform X16

      UniProtKB/TrEMBL
      B3KP60

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2938537..2977878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314171.1XP_054170146.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    2. XM_054314175.1XP_054170150.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

    3. XM_054314167.1XP_054170142.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

    4. XM_054314160.1XP_054170135.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    5. XM_054314170.1XP_054170145.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    6. XM_054314174.1XP_054170149.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

    7. XM_054314166.1XP_054170141.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

    8. XM_054314159.1XP_054170134.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    9. XM_054314163.1XP_054170138.1  FLYWCH-type zinc finger-containing protein 1 isoform X17

    10. XM_054314164.1XP_054170139.1  FLYWCH-type zinc finger-containing protein 1 isoform X4

    11. XM_054314168.1XP_054170143.1  FLYWCH-type zinc finger-containing protein 1 isoform X7

    12. XM_054314161.1XP_054170136.1  FLYWCH-type zinc finger-containing protein 1 isoform X2

    13. XM_054314162.1XP_054170137.1  FLYWCH-type zinc finger-containing protein 1 isoform X3

    14. XM_054314176.1XP_054170151.1  FLYWCH-type zinc finger-containing protein 1 isoform X10

    15. XM_054314177.1XP_054170152.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

    16. XM_054314181.1XP_054170156.1  FLYWCH-type zinc finger-containing protein 1 isoform X14

    17. XM_054314178.1XP_054170153.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

    18. XM_054314180.1XP_054170155.1  FLYWCH-type zinc finger-containing protein 1 isoform X12

    19. XM_054314165.1XP_054170140.1  FLYWCH-type zinc finger-containing protein 1 isoform X5

    20. XM_054314173.1XP_054170148.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

    21. XM_054314172.1XP_054170147.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    22. XM_054314169.1XP_054170144.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    23. XM_054314179.1XP_054170154.1  FLYWCH-type zinc finger-containing protein 1 isoform X13