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    IL1RL1 interleukin 1 receptor like 1 [ Homo sapiens (human) ]

    Gene ID: 9173, updated on 10-Dec-2024

    Summary

    Official Symbol
    IL1RL1provided by HGNC
    Official Full Name
    interleukin 1 receptor like 1provided by HGNC
    Primary source
    HGNC:HGNC:5998
    See related
    Ensembl:ENSG00000115602 MIM:601203; AllianceGenome:HGNC:5998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R
    Summary
    The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016]
    Expression
    Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL1RL1 in Genome Data Viewer
    Location:
    2q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102311563..102352356)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102769811..102810635)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102928023..102968497)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102803139-102803668 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:102813537-102814736 Neighboring gene interleukin 1 receptor like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851302-102851802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851803-102852303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102854175-102855374 Neighboring gene Sharpr-MPRA regulatory region 14071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102972025-102972526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16306 Neighboring gene interleukin 18 receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16307 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (11 hits/1256 screens)

    EBI GWAS Catalog

    Items 1 - 10 of 14
    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
    EBI GWAS Catalog
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    EBI GWAS Catalog
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    EBI GWAS Catalog
    Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
    EBI GWAS Catalog
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    EBI GWAS Catalog
    Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
    EBI GWAS Catalog
    Items 1 - 10 of 14

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    In vitro infection with HIV-1 subtype B upregulates ST2L expression in primary human astrocytes and SKNMC cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC32623, DKFZp564N1164

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating  
    enables cytokine receptor activity PubMed 
    enables interleukin-1 receptor activity  
    enables interleukin-33 binding  
    enables interleukin-33 receptor activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in cytosol  
    located_in external side of plasma membrane  
    located_in extracellular region  
    located_in focal adhesion  
    is_active_in plasma membrane  
    is_active_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    interleukin-1 receptor-like 1
    Names
    growth stimulation-expressed
    homolog of mouse growth stimulation-expressed
    interleukin 1 receptor-related protein
    NP_001269337.1
    NP_003847.2
    NP_057316.3
    XP_006712902.1
    XP_011510453.1
    XP_054200480.1
    XP_054200481.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282408.2 → NP_001269337.1  interleukin-1 receptor-like 1 isoform 3

      See identical proteins and their annotated locations for NP_001269337.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, cause translation initiation at a downstream start codon and translation termination at a different stop codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK303389, AL117622, BC030975, BQ012352
      Consensus CDS
      CCDS74548.1
      UniProtKB/Swiss-Prot
      Q01638
      Related
      ENSP00000384822.2, ENST00000404917.6
      Conserved Domains (2) summary
      cd05757
      Location:1 → 87
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:3 → 80
      IG_like; Immunoglobulin like
    2. NM_003856.4 → NP_003847.2  interleukin-1 receptor-like 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_003847.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks several 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL117622, BC030975, BQ012352
      Consensus CDS
      CCDS2058.1
      UniProtKB/TrEMBL
      E9PC41
      Related
      ENSP00000310371.2, ENST00000311734.6
      Conserved Domains (2) summary
      cd05756
      Location:16 → 104
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:118 → 204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    3. NM_016232.5 → NP_057316.3  interleukin-1 receptor-like 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057316.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB012701, AC007248, AK291578, DB063031
      Consensus CDS
      CCDS2057.1
      UniProtKB/Swiss-Prot
      A8K6B3, B4E0I3, Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
      Related
      ENSP00000233954.1, ENST00000233954.6
      Conserved Domains (4) summary
      cd05757
      Location:118 → 204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:21 → 104
      IG_like; Immunoglobulin like
      pfam01582
      Location:380 → 535
      TIR; TIR domain
      cl11960
      Location:16 → 104
      Ig; Immunoglobulin domain

    RNA

    1. NR_104167.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, an additional internal exon which includes a premature stop codon, and an alternate 3' segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB029084, AL117622, AL553735, BC030975, BQ012352, DA884586

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      102311563..102352356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512151.2 → XP_011510453.1  interleukin-1 receptor-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011510453.1

      UniProtKB/TrEMBL
      E9PC41
      Conserved Domains (2) summary
      cd05756
      Location:16 → 104
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:118 → 204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    2. XM_006712839.4 → XP_006712902.1  interleukin-1 receptor-like 1 isoform X2

      See identical proteins and their annotated locations for XP_006712902.1

      UniProtKB/Swiss-Prot
      A8K6B3, B4E0I3, Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
      Conserved Domains (4) summary
      cd05757
      Location:118 → 204
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:21 → 104
      IG_like; Immunoglobulin like
      pfam01582
      Location:380 → 535
      TIR; TIR domain
      cl11960
      Location:16 → 104
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      102769811..102810635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344505.1 → XP_054200480.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      E9PC41
    2. XM_054344506.1 → XP_054200481.1  interleukin-1 receptor-like 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K6B3, B4E0I3, Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44

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