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    TICAM2 TIR domain containing adaptor molecule 2 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102142245, updated on 7-Jun-2024

    Summary

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    Gene symbol
    TICAM2
    Gene description
    TIR domain containing adaptor molecule 2
    See related
    Ensembl:ENSMFAG00000019091
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TICAM2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 6 NC_088380.1 (122165146..122188692, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 6 NC_052260.1 (110846302..110869827, complement)

    Chromosome 6 - NC_088380.1Genomic Context describing neighboring genes Neighboring gene T-complex protein 1 subunit epsilon-like Neighboring gene fem-1 homolog C Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene uncharacterized LOC107130053

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425
    2. Rate of evolution in brain-expressed genes in humans and other primates. Wang HY, et al. PLoS Biol, 2007 Feb. PMID 17194215, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TRIF-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of myeloid dendritic cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TIR domain-containing adapter molecule 2
    Names
    toll like receptor adaptor molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088380.1 Reference T2T-MFA8v1.0

      Range
      122165146..122188692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015451416.3 → XP_015306902.1  TIR domain-containing adapter molecule 2

      UniProtKB/TrEMBL
      B3Y6A3
      Conserved Domains (1) summary
      cl23749
      Location:81 → 181
      TIR_2; TIR domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001285821.1: Suppressed sequence

      Description
      NM_001285821.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

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