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    Lrrn4cl LRRN4 C-terminal like [ Mus musculus (house mouse) ]

    Gene ID: 68852, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrn4clprovided by MGI
    Official Full Name
    LRRN4 C-terminal likeprovided by MGI
    Primary source
    MGI:MGI:1916102
    See related
    Ensembl:ENSMUSG00000071656 AllianceGenome:MGI:1916102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110067I12Rik
    Summary
    Predicted to be located in membrane. Orthologous to human LRRN4CL (LRRN4 C-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 5.9), bladder adult (RPKM 5.5) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrn4cl in Genome Data Viewer
    Location:
    19 A; 19 5.81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8828132..8831273)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8850768..8853909)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene STARR-seq mESC enhancer starr_45496 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene guanine nucleotide binding protein (G protein), gamma 3 Neighboring gene STARR-seq mESC enhancer starr_45500 Neighboring gene UBX domain protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:8955290-8955473 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. van der Weyden L, et al. Commun Biol, 2021 Mar 23. PMID 33758365, Free PMC Article
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation.
      Title: CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130183, MGC130184

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LRRN4 C-terminal-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013019.3 → NP_001013037.1  LRRN4 C-terminal-like protein precursor

      See identical proteins and their annotated locations for NP_001013037.1

      Status: VALIDATED

      Source sequence(s)
      AC129217, AK087615
      Consensus CDS
      CCDS37909.1
      UniProtKB/Swiss-Prot
      Q3TYX2
      Related
      ENSMUSP00000093976.3, ENSMUST00000096257.3
      Conserved Domains (1) summary
      cd00063
      Location:83 → 162
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001360628.1 → NP_001347557.1  LRRN4 C-terminal-like protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC129217, AK158268
      Consensus CDS
      CCDS37909.1
      UniProtKB/Swiss-Prot
      Q3TYX2
      Related
      ENSMUSP00000157980.2, ENSMUST00000235683.2
      Conserved Domains (1) summary
      cd00063
      Location:83 → 162
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8828132..8831273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYX2.1 GenPept UniProtKB/Swiss-Prot:Q3TYX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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