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    MIR9-1HG MIR9-1 host gene [ Homo sapiens (human) ]

    Gene ID: 10485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MIR9-1HGprovided by HGNC
    Official Full Name
    MIR9-1 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:30780
    See related
    Ensembl:ENSG00000125462 MIM:618747; AllianceGenome:HGNC:30780
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CROC4; C1orf61
    Summary
    Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward brain (RPKM 43.3) See more
    Orthologs
    all
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    Genomic context

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    See MIR9-1HG in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156404252..156429548, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155542856..155568152, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156374044..156399340, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1859 Neighboring gene TSSK6 activating cochaperone Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene Rh family B glycoprotein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene microRNA 9-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene myocyte enhancer factor 2D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene IQ motif containing GTPase activating protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib. Yu Y, et al. Biochim Biophys Acta Mol Cell Res, 2021 Jul. PMID 33915231
    2. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. Hu HM, et al. FASEB J, 2013 Jan. PMID 23012322
    3. Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. Reppe S, et al. Bone, 2010 Mar. PMID 19922823
    4. CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types. Jeffrey PL, et al. Mol Cell Neurosci, 2000 Sep. PMID 10995546
    5. LncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression through the miR-2392/C1orf61 pathway. Yang J, et al. J Cell Physiol, 2019 Aug. PMID 30908634

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib.
      Title: C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib.
    2. CACNA1G-AS1 promotes hepatocellular carcinoma progression through regulating the miR-2392/C1orf61 pathway.
      Title: LncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression through the miR-2392/C1orf61 pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • contingent replication of cDNA 4
    • protein CROC-4
    • transcriptional activator of the c-fos promoter

    Clone Names

    • FLJ38303

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_135260.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, BI667681, U49857
      Related
      ENST00000758279.1

    2. NR_135261.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, AL139130, BC010558, BG716287
      Related
      ENST00000703052.2

    3. NR_135262.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, BC010558, BG716287, BI597719
      Related
      ENST00000758275.1

    4. NR_135263.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, BC010558, BG716287, BI668594
      Related
      ENST00000310027.11

    5. NR_135264.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, BC010558, HY158402, U49857
      Related
      ENST00000357975.6

    6. NR_135265.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, AL139130, DB534652, HY121703
      Related
      ENST00000465270.7

    7. NR_135266.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, AL139130, DB534652, HY137784

    8. NR_135267.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, AL139130, DB534652, HY152089
      Related
      ENST00000497822.7

    9. NR_135268.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI264870, AL139130, BI752228, DB534652, HY152089
      Related
      ENST00000758336.1

    10. NR_168070.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139130
      Related
      ENST00000368243.8

    11. NR_168071.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139130
      Related
      ENST00000703058.2

    12. NR_168072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139130
      Related
      ENST00000701195.2

    13. NR_168073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139130
      Related
      ENST00000486517.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156404252..156429548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791758.1 Reference GRCh38.p14 PATCHES

      Range
      4968..15892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007069446.1 RNA Sequence

    2. XR_007069444.1 RNA Sequence

    3. XR_007069447.1 RNA Sequence

    4. XR_007069445.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155542856..155568152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001320453.1: Suppressed sequence

      Description
      NM_001320453.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    2. NM_001320454.2: Suppressed sequence

      Description
      NM_001320454.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    3. NM_001320455.2: Suppressed sequence

      Description
      NM_001320455.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    4. NM_006365.3: Suppressed sequence

      Description
      NM_006365.3: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13536.1 GenPept UniProtKB/Swiss-Prot:Q13536

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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