Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [Mus musculus (house mouse)] -

Summary

Official Symbol: Slc7a3provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 3provided by MGI
Primary source: MGI:MGI:1100521
See related: Ensembl:ENSMUSG00000031297 AllianceGenome:MGI:1100521
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAT3; Atrc3; CAT-3; SLC7A1; SLC7A2
Summary: The protein encoded by this gene is a member of the system y+ cationic amino acid transporter family. Proteins of this family allow uptake of arginine from extracellular media. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression: Broad expression in CNS E18 (RPKM 4.8), limb E14.5 (RPKM 1.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3- D; X 43.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (100122752..100134058, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (101079146..101090452, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
Title: Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
Slc7a3 expression is significantly induced by p53 upon glutamine deprivation.
Title: p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.
knockdown impaired AMPK-PPAR-alpha signaling and resulted in lipid accumulation under fasting
Title: Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
Title: Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc7a3 (e-PCR), detects polymorphism
- UniSTS:547360

U70859 (e-PCR)
- UniSTS:163622

Slc7a3 (e-PCR), detects polymorphism
- UniSTS:527023

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-arginine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-lysine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-lysine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-ornithine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-ornithine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables basic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables basic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-arginine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-arginine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-lysine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-lysine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-lysine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ornithine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-ornithine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysine transport	ISO Inferred from Sequence Orthology more info
involved_in ornithine transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: cationic amino acid transporter 3

Names: amino acid transporter, cationic 3; cationic amino acid transporter y+; solute carrier family 7 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301840.1 → NP_001288769.1 cationic amino acid transporter 3

See identical proteins and their annotated locations for NP_001288769.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK077593, AK141558

Consensus CDS

CCDS30309.1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Related

ENSMUSP00000073582.5, ENSMUST00000073927.5

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease
NM_007515.3 → NP_031541.1 cationic amino acid transporter 3

See identical proteins and their annotated locations for NP_031541.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK077593, AK141558, CD540305

Consensus CDS

CCDS30309.1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Related

ENSMUSP00000098914.2, ENSMUST00000101362.8

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

100122752..100134058 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247513.2 → XP_011245815.1 cationic amino acid transporter 3 isoform X1

See identical proteins and their annotated locations for XP_011245815.1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease
XM_006527753.3 → XP_006527816.1 cationic amino acid transporter 3 isoform X1

See identical proteins and their annotated locations for XP_006527816.1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Related

ENSMUSP00000109339.2, ENSMUST00000113710.8

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease
XM_036161792.1 → XP_036017685.1 cationic amino acid transporter 3 isoform X1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease
XM_036161793.1 → XP_036017686.1 cationic amino acid transporter 3 isoform X1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease
XM_036161791.1 → XP_036017684.1 cationic amino acid transporter 3 isoform X1

UniProtKB/Swiss-Prot

B1AVE2, P70423

UniProtKB/TrEMBL

Q3TMH5

Conserved Domains (1) summary

TIGR00906
Location:4 → 588

2A0303; cationic amino acid transport permease