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    Tmem225 transmembrane protein 225 [ Mus musculus (house mouse) ]

    Gene ID: 75667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem225provided by MGI
    Official Full Name
    transmembrane protein 225provided by MGI
    Primary source
    MGI:MGI:1922917
    See related
    Ensembl:ENSMUSG00000040541 AllianceGenome:MGI:1922917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tnen225; 1700030E15Rik
    Summary
    Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Involved in negative regulation of phosphatase activity. Located in inner acrosomal membrane and outer acrosomal membrane. Orthologous to human TMEM225 (transmembrane protein 225). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 39.4) See more
    Orthologs
    human all
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    Genomic context

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    See Tmem225 in Genome Data Viewer
    Location:
    9 A5.1; 9 21.42 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40059418..40062176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40148122..40150880)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily D member 4 Neighboring gene STARR-seq mESC enhancer starr_23845 Neighboring gene predicted gene, 35123 Neighboring gene Fcf1 pseudogene Neighboring gene olfactory receptor family 6 subfamily X member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice. Lv Z, et al. Mol Cell Proteomics, 2024 Feb. PMID 38246484, Free PMC Article
    2. TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa. Matsuura M, et al. Mol Reprod Dev, 2015 Feb. PMID 25605614
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice.
      Title: TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice.
    2. TMEM225 is involved in the differentiation and function of spermatozoa through the regulation of PP1gamma2 activity.
      Title: TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in inner acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 225

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359300.1 → NP_001346229.1  transmembrane protein 225 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC136021

    2. NM_029379.1 → NP_083655.1  transmembrane protein 225 isoform 1

      See identical proteins and their annotated locations for NP_083655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK006538, BX630292
      Consensus CDS
      CCDS52774.1
      UniProtKB/Swiss-Prot
      Q9D9S2
      Related
      ENSMUSP00000036816.8, ENSMUST00000046333.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      40059418..40062176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9S2.1 GenPept UniProtKB/Swiss-Prot:Q9D9S2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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