Rnf103 ring finger protein 103 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf103provided by MGI
Official Full Name: ring finger protein 103provided by MGI
Primary source: MGI:MGI:109483
See related: Ensembl:ENSMUSG00000052656 AllianceGenome:MGI:109483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: kf-1; Zfp103
Summary: This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in colon adult (RPKM 26.1), duodenum adult (RPKM 20.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.16 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (71470828..71487864)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (71493844..71510880)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies indicate that the kf-1 null mice should be useful in elucidating the molecular mechanisms of the anxiety regulation.
Title: KF-1 ubiquitin ligase: anxiety suppressor model.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_24177-24178:1033563974:1 (e-PCR)
- UniSTS:268851

AW146237 (e-PCR)
- UniSTS:179393

NoName (e-PCR)
- UniSTS:235467

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF103

Names: RING-type E3 ubiquitin transferase RNF103; zinc finger protein 103

NP_001295232.1

EC 2.3.2.27

NP_001397436.1

EC 2.3.2.27

NP_001397437.1

EC 2.3.2.27

NP_033569.2

EC 2.3.2.27

XP_036021921.1

EC 2.3.2.27

XP_036021922.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308303.2 → NP_001295232.1 E3 ubiquitin-protein ligase RNF103 isoform 2

See identical proteins and their annotated locations for NP_001295232.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in its 3' terminal exon, resulting in a distinct 5' UTR and the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4 all encode the same isoform (2).

Source sequence(s)

AC154001

UniProtKB/TrEMBL

Q3TGP6

Conserved Domains (1) summary

cd16473
Location:444 → 489

RING-H2_RNF103; RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins
NM_001410507.1 → NP_001397436.1 E3 ubiquitin-protein ligase RNF103 isoform 2

Status: REVIEWED

Source sequence(s)

AC154001

UniProtKB/TrEMBL

Q3TGP6
NM_001410508.1 → NP_001397437.1 E3 ubiquitin-protein ligase RNF103 isoform 2

Status: REVIEWED

Source sequence(s)

AC154001

UniProtKB/TrEMBL

Q3TGP6
NM_009543.4 → NP_033569.2 E3 ubiquitin-protein ligase RNF103 isoform 1

See identical proteins and their annotated locations for NP_033569.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC154001

Consensus CDS

CCDS39508.1

UniProtKB/Swiss-Prot

B9EHC2, O08670, O08883, Q9R1W3

Related

ENSMUSP00000066324.5, ENSMUST00000064637.11

Conserved Domains (1) summary

cd00162
Location:618 → 661

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...