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    SIRT7 sirtuin 7 [ Homo sapiens (human) ]

    Gene ID: 51547, updated on 27-Nov-2024

    Summary

    Official Symbol
    SIRT7provided by HGNC
    Official Full Name
    sirtuin 7provided by HGNC
    Primary source
    HGNC:HGNC:14935
    See related
    Ensembl:ENSG00000187531 MIM:606212; AllianceGenome:HGNC:14935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2L7
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SIRT7 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81911939..81918176, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82779099..82785336, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876052, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9161 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79850899-79851114 Neighboring gene anaphase promoting complex subunit 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9164 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12984 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:79880785-79881984 Neighboring gene MAF bZIP transcription factor G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79882682-79883637 Neighboring gene MAFG antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9171 Neighboring gene MYC inducible lncRNA inactivating p53

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126840, MGC126842

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD-dependent protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein-lysine depropionylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K14 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K18 deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K18 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K18 deacetylase activity, NAD-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K4 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-glutaryllysine deglutarylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-glutaryllysine deglutarylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-succinyllysine desuccinylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-succinyllysine desuccinylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in R-loop processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homologous chromosome pairing at meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of rRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deglutarylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein depropionylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transposable element silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus organizer region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-7
    Names
    NAD-dependent deacetylase sirtuin-7
    NAD-dependent protein deacylase sirtuin-7
    SIR2-like protein 7
    regulatory protein SIR2 homolog 7
    silent mating type information regulation 2, S.cerevisiae, homolog 7
    sir2-related protein type 7
    sirtuin type 7
    NP_057622.1
    XP_011521882.1
    XP_047292184.1
    XP_047292185.1
    XP_047292186.1
    XP_047292187.1
    XP_054172376.1
    XP_054172377.1
    XP_054172378.1
    XP_054172379.1
    XP_054172380.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016538.3NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

      See identical proteins and their annotated locations for NP_057622.1

      Status: REVIEWED

      Source sequence(s)
      BC017305, BC101791, BQ890203, CD579273
      Consensus CDS
      CCDS11792.1
      UniProtKB/Swiss-Prot
      A8K2K0, B3KSU8, Q3MIK4, Q9NRC8, Q9NSZ6, Q9NUS6
      Related
      ENSP00000329466.6, ENST00000328666.11
      Conserved Domains (2) summary
      COG1196
      Location:794
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01410
      Location:100314
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81911939..81918176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523580.2XP_011521882.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

      See identical proteins and their annotated locations for XP_011521882.1

      Conserved Domains (1) summary
      cd01410
      Location:78279
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    2. XM_047436229.1XP_047292185.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

    3. XM_047436228.1XP_047292184.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

    4. XM_047436231.1XP_047292187.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

    5. XM_047436230.1XP_047292186.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82779099..82785336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316401.1XP_054172376.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

    2. XM_054316403.1XP_054172378.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

    3. XM_054316402.1XP_054172377.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

    4. XM_054316405.1XP_054172380.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

    5. XM_054316404.1XP_054172379.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4