GBP1 guanylate binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GBP1provided by HGNC
Official Full Name: guanylate binding protein 1provided by HGNC
Primary source: HGNC:HGNC:4182
See related: Ensembl:ENSG00000117228 MIM:600411; AllianceGenome:HGNC:4182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hGBP1
Summary: Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Expression: Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p22.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (89052319..89065208, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (88895700..88908571, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (89518002..89530891, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.
Title: Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.
GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1.
Title: GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1.
Interferon-gamma-induced GBP1 is an inhibitor of human papillomavirus 18.
Title: Interferon-γ-induced GBP1 is an inhibitor of human papillomavirus 18.
Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
Title: Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
Function and mechanism of GBP1 in the development and progression of cervical cancer.
Title: Function and mechanism of GBP1 in the development and progression of cervical cancer.
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation.
Title: Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation.
BRCA1-associated RING domain-1 (BARD1) loss and GBP1 expression enhance sensitivity to DNA damage in Ewing sarcoma.
Title: BRCA1-associated RING domain-1 (BARD1) loss and GBP1 expression enhance sensitivity to DNA damage in Ewing sarcoma.
Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.
Title: Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.
Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
Title: Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis.
Title: Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of interferon-inducible guanylate-binding protein 1 (GBP1) in human B cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-12771 (e-PCR)
- UniSTS:16951

SHGC-30461 (e-PCR)
- UniSTS:19393

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GDP phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables spectrin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis in another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to vacuole	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in symbiont cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate-binding protein 1

Names: GBP-1; GTP-binding protein 1; guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible, 67kDa; huGBP-1; interferon-induced guanylate-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002053.3 → NP_002044.2 guanylate-binding protein 1

See identical proteins and their annotated locations for NP_002044.2

Status: VALIDATED

Source sequence(s)

AK291783, BF058809, CB164272, CD676970

Consensus CDS

CCDS718.1

UniProtKB/Swiss-Prot

D3DT26, P32455, Q5T8M1

UniProtKB/TrEMBL

Q5D1D5

Related

ENSP00000359504.4, ENST00000370473.5

Conserved Domains (3) summary

pfam02841
Location:284 → 580

GBP_C; Guanylate-binding protein, C-terminal domain

pfam02263
Location:18 → 282

GBP; Guanylate-binding protein, N-terminal domain

cd16269
Location:290 → 580

GBP_C; Guanylate-binding protein, C-terminal domain