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    Exoc2 exocyst complex component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171455, updated on 9-Dec-2024

    Summary

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    Symbol
    Exoc2provided by RGD
    Full Name
    exocyst complex component 2provided by RGD
    Primary source
    RGD:619961
    See related
    EnsemblRapid:ENSRNOG00000060266 AllianceGenome:RGD:619961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rsec5; Sec5l1
    Summary
    Predicted to enable protein kinase binding activity and small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; regulation of entry of bacterium into host cell; and vesicle docking involved in exocytosis. Part of exocyst. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 188.9), Lung (RPKM 164.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Exoc2 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (33714949..33906901)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (33506289..33698246)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (34665810..34842266)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694077 Neighboring gene ribosomal protein S9, pseudogene 1 Neighboring gene ribosomal protein S11, pseudogene 4 Neighboring gene uncharacterized LOC120097838 Neighboring gene HUS1 checkpoint clamp component B Neighboring gene microRNA mir-6319-1 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene interferon regulatory factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. Fukai S, et al. EMBO J, 2003 Jul 1. PMID 12839989, Free PMC Article
    2. Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. Mott HR, et al. J Biol Chem, 2003 May 9. PMID 12624092
    3. The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Sugihara K, et al. Nat Cell Biol, 2002 Jan. PMID 11744922
    4. Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Nichols CD, et al. Curr Biol, 2010 Jul 27. PMID 20579884, Free PMC Article
    5. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Saito T, et al. Biomed Res, 2008 Apr. PMID 18480549

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of entry of bacterium into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of entry of bacterium into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 2
    Names
    exocyst complex component Sec5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134414.2 → NP_599241.2  exocyst complex component 2

      Status: VALIDATED

      Source sequence(s)
      AA875297, AF032666, BP475684, CB582051, CK482593, CO393045, CO396803, DV724419
      UniProtKB/Swiss-Prot
      O54921
      Related
      ENSRNOP00000071882.3, ENSRNOT00000089613.3
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:198 → 377
      Sec5; Exocyst complex component Sec5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      33714949..33906901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095323.2 → XP_038951251.1  exocyst complex component 2 isoform X1

      UniProtKB/TrEMBL
      F1LMB9
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:224 → 400
      Sec5; Exocyst complex component Sec5

    2. XM_039095327.2 → XP_038951255.1  exocyst complex component 2 isoform X5

      UniProtKB/TrEMBL
      F1LMB9
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:224 → 400
      Sec5; Exocyst complex component Sec5

    3. XM_039095324.2 → XP_038951252.1  exocyst complex component 2 isoform X2

      UniProtKB/TrEMBL
      F1LMB9
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:224 → 400
      Sec5; Exocyst complex component Sec5

    4. XM_039095320.2 → XP_038951248.1  exocyst complex component 2 isoform X1

      UniProtKB/TrEMBL
      F1LMB9
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:224 → 400
      Sec5; Exocyst complex component Sec5

    5. XM_039095325.2 → XP_038951253.1  exocyst complex component 2 isoform X3

      UniProtKB/TrEMBL
      F1LMB9
      Related
      ENSRNOP00000072436.2, ENSRNOT00000077110.3
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    6. XM_006253891.3 → XP_006253953.1  exocyst complex component 2 isoform X4

      See identical proteins and their annotated locations for XP_006253953.1

      UniProtKB/Swiss-Prot
      O54921
      UniProtKB/TrEMBL
      A0A0G2K416
      Related
      ENSRNOP00000072864.2, ENSRNOT00000090706.3
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:222 → 401
      Sec5; Exocyst complex component Sec5

    7. XM_063276039.1 → XP_063132109.1  exocyst complex component 2 isoform X6

      UniProtKB/Swiss-Prot
      O54921
      Related
      ENSRNOP00000111482.1, ENSRNOT00000155008.1

    8. XM_063276041.1 → XP_063132111.1  exocyst complex component 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K1K8

    9. XM_063276040.1 → XP_063132110.1  exocyst complex component 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K1K8

    10. XM_039095321.2 → XP_038951249.1  exocyst complex component 2 isoform X1

      UniProtKB/TrEMBL
      F1LMB9
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:224 → 400
      Sec5; Exocyst complex component Sec5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54921.1 GenPept UniProtKB/Swiss-Prot:O54921

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