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    Psmg2 proteasome assembly chaperone 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmg2provided by RGD
    Official Full Name
    proteasome assembly chaperone 2provided by RGD
    Primary source
    RGD:1304867
    See related
    AllianceGenome:RGD:1304867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnfsf5ip1
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in chaperone-mediated protein complex assembly and proteasome assembly. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling and negative regulation of apoptotic process. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 4. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 98.9), Thymus (RPKM 92.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmg2 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63478620..63493193)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61208669..61227671)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63394991..63420491)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene spire-type actin nucleation factor 1 Neighboring gene centrosomal protein 76 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene uncharacterized LOC134482957 Neighboring gene thymosin, beta 10 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. Bahar R, et al. J Biol Chem, 2002 Oct 18. PMID 12147697
    2. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
    3. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Hirano Y, et al. Nature, 2005 Oct 27. PMID 16251969
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proteasome assembly chaperone 2
    Names
    proteasome (prosome, macropain) assembly chaperone 2
    tumor necrosis factor superfamily, member 5-induced protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106138.2 → NP_001099608.2  proteasome assembly chaperone 2

      Status: VALIDATED

      Source sequence(s)
      BM387084, CB798672, DV720222
      UniProtKB/TrEMBL
      A0A8I6G3H9, D3ZAQ4
      Conserved Domains (1) summary
      pfam09754
      Location:17 → 123
      PAC2; PAC2 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63478620..63493193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277192.1 → XP_063133262.1  proteasome assembly chaperone 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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