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    Gxylt1 glucoside xylosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gxylt1provided by RGD
    Official Full Name
    glucoside xylosyltransferase 1provided by RGD
    Primary source
    RGD:1563062
    See related
    EnsemblRapid:ENSRNOG00000005234 AllianceGenome:RGD:1563062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glt8d3
    Summary
    Predicted to enable UDP-xylosyltransferase activity. Predicted to be involved in O-glycan processing. Predicted to be located in membrane. Orthologous to human GXYLT1 (glucoside xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 69.3), Lung (RPKM 58.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gxylt1 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (126280349..126320803, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (124400896..124434682, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (134447578..134495858, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479776 Neighboring gene uncharacterized LOC102552792 Neighboring gene uncharacterized LOC134479777 Neighboring gene YY1 associated factor 2 Neighboring gene 60S ribosomal protein L30 pseudogene Neighboring gene uncharacterized LOC134479778

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. Sethi MK, et al. J Biol Chem, 2010 Jan 15. PMID 19940119, Free PMC Article
    2. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Iwanaga R, et al. Oncogene, 2006 Mar 16. PMID 16288221
    3. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Pandey A, et al. Glycobiology, 2018 Nov 1. PMID 30169771, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-xylosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in O-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in O-glycan processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucoside xylosyltransferase 1
    Names
    S33-D
    glycosyltransferase 8 domain containing 3
    glycosyltransferase 8 domain-containing protein 3
    NP_001094357.1
    XP_006242254.1
    XP_038934832.1
    XP_038934833.1
    XP_038934834.1
    XP_038934835.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100887.1 → NP_001094357.1  glucoside xylosyltransferase 1

      See identical proteins and their annotated locations for NP_001094357.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q6GX83
      UniProtKB/TrEMBL
      A6K7S6
      Related
      ENSRNOP00000055150.2, ENSRNOT00000058349.5
      Conserved Domains (2) summary
      cd06430
      Location:111 → 411
      GT8_like_2; GT8_like_2 represents a subfamily of GT8 with unknown function
      COG1442
      Location:183 → 340
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      126280349..126320803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242192.5 → XP_006242254.1  glucoside xylosyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFF2, A6K7S5
      Related
      ENSRNOP00000091433.1, ENSRNOT00000099240.2
      Conserved Domains (2) summary
      cd06430
      Location:80 → 380
      GT8_like_2; GT8_like_2 represents a subfamily of GT8 with unknown function
      COG1442
      Location:152 → 309
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    2. XM_039078904.2 → XP_038934832.1  glucoside xylosyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      B2RZ91
      Related
      ENSRNOP00000073028.1, ENSRNOT00000081104.3
      Conserved Domains (1) summary
      cd06430
      Location:1 → 301
      GT8_like_2; GT8_like_2 represents a subfamily of GT8 with unknown function

    3. XM_039078907.2 → XP_038934835.1  glucoside xylosyltransferase 1 isoform X5

      Conserved Domains (1) summary
      cl11394
      Location:4 → 225
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_039078906.2 → XP_038934834.1  glucoside xylosyltransferase 1 isoform X4

      Conserved Domains (1) summary
      cl11394
      Location:80 → 252
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    5. XM_039078905.2 → XP_038934833.1  glucoside xylosyltransferase 1 isoform X3

      Conserved Domains (1) summary
      cl11394
      Location:111 → 283
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GX83.2 GenPept UniProtKB/Swiss-Prot:Q6GX83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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