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    Upk1a uroplakin 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Upk1aprovided by RGD
    Official Full Name
    uroplakin 1Aprovided by RGD
    Primary source
    RGD:1309849
    See related
    EnsemblRapid:ENSRNOG00000024331 AllianceGenome:RGD:1309849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in epithelial cell differentiation. Predicted to be located in apical plasma membrane and cell surface. Predicted to be active in apical plasma membrane urothelial plaque. Orthologous to human UPK1A (uroplakin 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 19.9), Testes (RPKM 6.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Upk1a in Genome Data Viewer
    Location:
    1q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94987110..94998083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85859672..85870147, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89060581..89071579, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2B Neighboring gene microRNA 3569 Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene cytochrome c oxidase subunit 6B1 Neighboring gene ETS variant transcription factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Zupančič D, et al. Virchows Arch, 2011 May. PMID 21301865
    2. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. Zhou G, et al. J Cell Sci, 2001 Nov. PMID 11739641
    3. Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection. Hashimoto J, et al. J Immunol, 2017 Apr 1. PMID 28228557
    4. Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Ogawa K, et al. Am J Pathol, 1999 Oct. PMID 10514386, Free PMC Article
    5. Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. Wu XR, et al. J Biol Chem, 1994 May 6. PMID 8175808

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions
      Title: Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in apical plasma membrane urothelial plaque ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uroplakin-1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108911.2 → NP_001102381.2  uroplakin-1a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A1L2C162, A0A8I5ZVR2
      Related
      ENSRNOP00000097413.1, ENSRNOT00000105462.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94987110..94998083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269124.1 → XP_063125194.1  uroplakin-1a isoform X4

      UniProtKB/TrEMBL
      A0A1L2C162, A0A8I5ZVR2

    2. XM_063269118.1 → XP_063125188.1  uroplakin-1a isoform X2

      UniProtKB/TrEMBL
      D3ZDW5
      Related
      ENSRNOP00000103035.1, ENSRNOT00000141071.1

    3. XM_063269121.1 → XP_063125191.1  uroplakin-1a isoform X2

      UniProtKB/TrEMBL
      D3ZDW5

    4. XM_039084978.2 → XP_038940906.1  uroplakin-1a isoform X5

      UniProtKB/TrEMBL
      D3ZDW5
      Conserved Domains (1) summary
      cd03156
      Location:113 → 217
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    5. XM_063269116.1 → XP_063125186.1  uroplakin-1a isoform X1

    6. XM_063269122.1 → XP_063125192.1  uroplakin-1a isoform X3

      UniProtKB/TrEMBL
      D3ZDW5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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