Spp1 secreted phosphoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Spp1provided by RGD
Full Name: secreted phosphoprotein 1provided by RGD
Primary source: RGD:3752
See related: EnsemblRapid:ENSRNOG00000043451 AllianceGenome:RGD:3752
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OSP
Summary: Predicted to enable extracellular matrix binding activity; integrin binding activity; and small molecule binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; and response to macrophage colony-stimulating factor. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 3427.7), Adrenal (RPKM 462.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (5613569..5620695, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (5308885..5315120, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (6673686..6679965, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury-induced neuropathic pain: Regulating extracellular signal-regulated kinase and neuroinflammatory signaling pathways.
Title: Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury-induced neuropathic pain: Regulating extracellular signal-regulated kinase and neuroinflammatory signaling pathways.
[Role of SPP1 in acute kidney injury induced by renal ischemia-reperfusion in rats].
Title: [Role of SPP1 in acute kidney injury induced by renal ischemia-reperfusion in rats].
Downregulation of RUNX1-Activated Osteopontin Facilitates Burn Wound Healing by Activating the MAPK Pathways.
Title: Downregulation of RUNX1-Activated Osteopontin Facilitates Burn Wound Healing by Activating the MAPK Pathways.
A miR-340/SPP1 axis inhibits the activation and proliferation of hepatic stellate cells by inhibiting the TGF-beta1/Smads pathway.
Title: A miR-340/SPP1 axis inhibits the activation and proliferation of hepatic stellate cells by inhibiting the TGF-β1/Smads pathway.
Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access.
Title: Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access.
Osteopontin mediates the formation of corpora amylacea-like structures from degenerating neurons in the CA1 region of the rat hippocampus after ischemia.
Title: Osteopontin mediates the formation of corpora amylacea-like structures from degenerating neurons in the CA1 region of the rat hippocampus after ischemia.
Osteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype.
Title: Osteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype.
Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.
Title: Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.
Tramadol aggravates cardiovascular toxicity in a rat model of alcoholism: Involvement of intermediate microfilament proteins and immune-expressed osteopontin.
Title: Tramadol aggravates cardiovascular toxicity in a rat model of alcoholism: Involvement of intermediate microfilament proteins and immune-expressed osteopontin.
Role of osteopontin in diet-induced brown gallstone formation in rats.
Title: Role of osteopontin in diet-induced brown gallstone formation in rats.

Submit: New GeneRIF Correction See all GeneRIFs (126)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129494 (e-PCR)
- UniSTS:212798

UniSTS:280407 (e-PCR)
- UniSTS:280407

Spp1 (e-PCR), detects polymorphism
- UniSTS:280407

RH94678 (e-PCR)
- UniSTS:119925

PMC316977P2 (e-PCR)
- UniSTS:273067

RH136964 (e-PCR)
- UniSTS:219053

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to fluid shear stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to testosterone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collecting duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collateral sprouting of intact axon in response to injury	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of bone resorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of estradiol secretion	ISO Inferred from Sequence Orthology more info
involved_in response to 2,3,7,8-tetrachlorodibenzodioxine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to macrophage colony-stimulating factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to vitamin D	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: osteopontin

Names: SPP-1; Sialoprotein (osteopontin); bone sialoprotein 1; osteopontin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.