Slc43a2 solute carrier family 43, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc43a2provided by MGI
Official Full Name: solute carrier family 43, member 2provided by MGI
Primary source: MGI:MGI:2442746
See related: Ensembl:ENSMUSG00000038178 AllianceGenome:MGI:2442746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lat4; 7630402D21Rik
Summary: Enables L-leucine transmembrane transporter activity and L-phenylalanine transmembrane transporter activity. Involved in L-leucine transport and phenylalanine transport. Acts upstream of or within L-amino acid transport. Located in basolateral plasma membrane. Is expressed in several structures, including adrenal medulla; metanephros; nephric duct of male; nervous system; and sensory organ. Orthologous to human SLC43A2 (solute carrier family 43 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in duodenum adult (RPKM 79.3), small intestine adult (RPKM 65.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75420741..75468401)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75529915..75577575)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
Title: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.
Title: Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.
LAT4 is subject to a circadian regulation by phosphorylation in the mouse small intestine, and this novel regulatory mechanism is suggested to play an important role in the diurnal regulation of amino acid absorption.
Title: Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function.
Mice lacking Lat4 display a slight intrauterine growth restriction, postnatal malnutrition and early death.
Title: Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development.
In situ hybridization experiments show that LAT4 mRNA is restricted to the epithelial cells of the distal tubule and the collecting duct in the kidney. In the intestine, LAT4 is mainly present in the cells of the crypt.
Title: Identification of LAT4, a novel amino acid transporter with system L activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc43a2 (e-PCR), detects polymorphism
- UniSTS:547345

D11Jcs7 (e-PCR), detects polymorphism
- UniSTS:461963

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-isoleucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-isoleucine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-leucine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-methionine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-methionine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-phenylalanine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-phenylalanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in isoleucine transport	ISO Inferred from Sequence Orthology more info
involved_in isoleucine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in methionine transport	ISO Inferred from Sequence Orthology more info
involved_in methionine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of L-leucine import across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylalanine transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: large neutral amino acids transporter small subunit 4

Names: L-type amino L-acid transporter 4; L-type amino acid transporter 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199283.1 → NP_001186212.1 large neutral amino acids transporter small subunit 4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AA017978, AK143773, AL591440, AL591496

Consensus CDS

CCDS25051.1

UniProtKB/Swiss-Prot

Q5CD76, Q8CGA3

Related

ENSMUSP00000126838.3, ENSMUST00000169547.9

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
NM_001199284.1 → NP_001186213.1 large neutral amino acids transporter small subunit 4

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different segment from its 5' UTR, compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AA017978, AB120363, AK143773, AL591440, BY202700

Consensus CDS

CCDS25051.1

UniProtKB/Swiss-Prot

Q5CD76, Q8CGA3

Related

ENSMUSP00000104071.2, ENSMUST00000108433.8

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
NM_173388.2 → NP_775564.1 large neutral amino acids transporter small subunit 4

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains a different segment from its 5' UTR, compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AA017978, AK143773, AL591440, BY202700, CD550550

Consensus CDS

CCDS25051.1

UniProtKB/Swiss-Prot

Q5CD76, Q8CGA3

Related

ENSMUSP00000046074.8, ENSMUST00000042561.14

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

75420741..75468401

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532825.4 → XP_006532888.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_030245780.2 → XP_030101640.1 large neutral amino acids transporter small subunit 4 isoform X2

UniProtKB/Swiss-Prot

Q5CD76, Q8CGA3

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532819.4 → XP_006532882.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532827.5 → XP_006532890.1 large neutral amino acids transporter small subunit 4 isoform X2

UniProtKB/Swiss-Prot

Q5CD76, Q8CGA3

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_036156511.1 → XP_036012404.1 large neutral amino acids transporter small subunit 4 isoform X2

UniProtKB/Swiss-Prot

Q5CD76, Q8CGA3

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532826.5 → XP_006532889.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532820.4 → XP_006532883.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532823.4 → XP_006532886.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532821.4 → XP_006532884.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532824.4 → XP_006532887.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_006532822.5 → XP_006532885.1 large neutral amino acids transporter small subunit 4 isoform X1

Conserved Domains (1) summary

cd06174
Location:90 → 239

MFS; Major Facilitator Superfamily
XM_036156512.1 → XP_036012405.1 large neutral amino acids transporter small subunit 4 isoform X3