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    TOP3A topoisomerase (DNA) III alpha [ Gallus gallus (chicken) ]

    Gene ID: 416517, updated on 3-Dec-2024

    Summary

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    Symbol
    TOP3Aprovided by CGNC
    Full Name
    topoisomerase (DNA) III alphaprovided by CGNC
    Primary source
    CGNC:3738
    See related
    Ensembl:ENSGALG00010017734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TOP3A in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (5088786..5100681, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (5083690..5095577, complement)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene FLII, actin remodeling protein Neighboring gene mitochondrial elongation factor 2 Neighboring gene Smith-Magenis syndrome chromosome region, candidate 8 Neighboring gene serine hydroxymethyltransferase 1 Neighboring gene chemokine-like receptor 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids. Seki M, et al. Mol Cell Biol, 2006 Aug. PMID 16880537, Free PMC Article
    2. Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome. Hoadley KA, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22392978, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate that BLM and Top3alpha execute the dissolution of sister chromatids.
      Title: Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 3-alpha
    Names
    DNA topoisomerase III alpha
    topoisomerase III alpha
    NP_001243419.1
    NP_001243420.1
    NP_001243421.1
    NP_001383105.1
    XP_046756565.1
    XP_046756566.1
    XP_046756567.1
    XP_046783326.1
    XP_046783327.1
    XP_046783328.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256490.2 → NP_001243419.1  DNA topoisomerase 3-alpha isoform 2

      See identical proteins and their annotated locations for NP_001243419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BX930143, JAENSK010000257
      UniProtKB/TrEMBL
      A0A1D5NT91
      Conserved Domains (1) summary
      cl00718
      Location:37 → 107
      TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...

    2. NM_001256491.2 → NP_001243420.1  DNA topoisomerase 3-alpha isoform 2

      See identical proteins and their annotated locations for NP_001243420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000257
      UniProtKB/TrEMBL
      A0A1D5NT91
      Conserved Domains (1) summary
      cl00718
      Location:37 → 107
      TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...

    3. NM_001256492.1 → NP_001243421.1  DNA topoisomerase 3-alpha isoform 3

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (4) lacks an internal exon and multiple exons at the 3' end. Its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BX930143, BX932024, BX935901
      UniProtKB/TrEMBL
      A0A1D5NT91
      Related
      ENSGALP00010025363.1, ENSGALT00010042873.1
      Conserved Domains (1) summary
      cl00718
      Location:37 → 87
      TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...

    4. NM_001396176.1 → NP_001383105.1  DNA topoisomerase 3-alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000257
      UniProtKB/TrEMBL
      A0A8V0Z377, Q4W5X0
      Conserved Domains (4) summary
      cd03362
      Location:37 → 195
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      cd00186
      Location:204 → 619
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam01396
      Location:657 → 695
      zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
      pfam06839
      Location:916 → 958
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      5088786..5100681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046900611.1 → XP_046756567.1  DNA topoisomerase 3-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z377, Q4W5X0
      Related
      ENSGALP00010025367.1, ENSGALT00010042877.1

    2. XM_046900609.1 → XP_046756565.1  DNA topoisomerase 3-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z377, Q4W5X0

    3. XM_046900610.1 → XP_046756566.1  DNA topoisomerase 3-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z377, Q4W5X0

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      5083690..5095577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046927372.1 → XP_046783328.1  DNA topoisomerase 3-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z377

    2. XM_046927370.1 → XP_046783326.1  DNA topoisomerase 3-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z377

    3. XM_046927371.1 → XP_046783327.1  DNA topoisomerase 3-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z377

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001030636.2: Suppressed sequence

      Description
      NM_001030636.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials