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    MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Gallus gallus (chicken) ]

    Gene ID: 424225, updated on 3-Dec-2024

    Summary

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    Symbol
    MAP3K2provided by CGNC
    Full Name
    mitogen-activated protein kinase kinase kinase 2provided by CGNC
    Primary source
    CGNC:8740
    See related
    Ensembl:ENSGALG00010021275
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See MAP3K2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (23203270..23251223)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (23122278..23170216)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 5 Neighboring gene peroxisomal trans-2-enoyl-CoA reductase Neighboring gene transmembrane protein 169 Neighboring gene uncharacterized LOC121111318 Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene cytochrome P450 family 27 subfamily C member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting. Zhang X, et al. Sci Rep, 2017 Nov 20. PMID 29158522, Free PMC Article
    2. Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens. Rengaraj D, et al. Asian-Australas J Anim Sci, 2017 Jul. PMID 28111433, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data indicated that miR-17-92 promotes chicken cell proliferation at least in part by the upregulation of c-Myc via targeting MAP3K2, and the miR-17-92 cluster, c-Myc and E2F1 form a complex regulatory network in chicken cell proliferation
      Title: MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting.
    2. Real-time qPCR results revealed that the downregulation of chicken miRNA gga-miR-20b-5p in the intestinal mucosal layer of Necrotic enteritis induced Fayoumi chicken line M5.1 was associated with the upregulation of its top-ranking target gene MAP3K2.
      Title: Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    XP_015145528.1
    XP_015145531.1
    XP_040532572.1
    XP_040532573.1
    XP_040532574.1
    XP_040532575.1
    XP_040559818.1
    XP_046778104.1
    XP_046778105.1
    XP_046778106.1
    XP_046778107.1
    XP_046778108.1
    XP_046799674.1
    XP_046799675.1
    XP_046799676.1
    XP_046799677.1
    XP_046799678.1
    XP_422075.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      23203270..23251223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943720.1 → XP_046799676.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4
      Related
      ENSGALP00010030769.1, ENSGALT00010051583.1

    2. XM_046943722.1 → XP_046799678.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4

    3. XM_015290045.4 → XP_015145531.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4
      Related
      ENSGALP00010030773.1, ENSGALT00010051589.1
      Conserved Domains (2) summary
      cd06405
      Location:34 → 111
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:348 → 611
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    4. XM_422075.8 → XP_422075.3  mitogen-activated protein kinase kinase kinase 2 isoform X3

      See identical proteins and their annotated locations for XP_422075.3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4
      Conserved Domains (2) summary
      cd06405
      Location:34 → 111
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:348 → 611
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    5. XM_015290042.4 → XP_015145528.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZJ31
      Related
      ENSGALP00010030775.1, ENSGALT00010051592.1
      Conserved Domains (2) summary
      cd06405
      Location:44 → 121
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:358 → 621
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    6. XM_040703884.2 → XP_040559818.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZHJ3
      Conserved Domains (2) summary
      cd06405
      Location:44 → 121
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:357 → 620
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    7. XM_046943721.1 → XP_046799677.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4

    8. XM_046943718.1 → XP_046799674.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZJ31

    9. XM_046943719.1 → XP_046799675.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZJ31

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      23122278..23170216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046922150.1 → XP_046778106.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4

    2. XM_046922152.1 → XP_046778108.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4

    3. XM_040676640.2 → XP_040532574.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4
      Conserved Domains (2) summary
      cd06405
      Location:34 → 111
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:348 → 611
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    4. XM_040676641.2 → XP_040532575.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4
      Conserved Domains (2) summary
      cd06405
      Location:34 → 111
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:348 → 611
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    5. XM_040676638.2 → XP_040532572.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZJ31
      Conserved Domains (2) summary
      cd06405
      Location:44 → 121
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:358 → 621
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    6. XM_040676639.2 → XP_040532573.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZHJ3
      Conserved Domains (2) summary
      cd06405
      Location:44 → 121
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:357 → 620
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    7. XM_046922151.1 → XP_046778107.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZPW4

    8. XM_046922148.1 → XP_046778104.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZJ31

    9. XM_046922149.1 → XP_046778105.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZHJ3, A0A8V0ZJ31
    Nucleotide Protein Strain
    Heading Accession and Version

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