ARHGEF12 Rho guanine nucleotide exchange factor 12 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: ARHGEF12provided by CGNC
Official Full Name: Rho guanine nucleotide exchange factor 12provided by CGNC
Primary source: CGNC:51082
See related: Ensembl:ENSGALG00010025907
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 24

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	24	NC_052555.1 (3770779..3836907, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	24	NC_052596.1 (3730184..3796335, complement)

Chromosome 24 - NC_052555.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-RGMa activates the Leukemia-associated RhoGEF (LARG)/Rho/Rock pathway to block axonal growth.
Title: ϒ-secretase and LARG mediate distinct RGMa activities to control appropriate layer targeting within the optic tectum.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: rho guanine nucleotide exchange factor 12

Names: Rho guanine nucleotide exchange factor (GEF) 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3770779..3836907 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040652160.2 → XP_040508094.1 rho guanine nucleotide exchange factor 12 isoform X3

UniProtKB/TrEMBL

A0A8V0ZZF0

Related

ENSGALP00010038988.1, ENSGALT00010063168.1

Conserved Domains (4) summary

cd08754
Location:328 → 549

RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)

smart00325
Location:770 → 955

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:53 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13390
Location:974 → 1111

PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_040652159.2 → XP_040508093.1 rho guanine nucleotide exchange factor 12 isoform X2

UniProtKB/TrEMBL

F1P1Y1

Related

ENSGALP00010039013.1, ENSGALT00010063202.1

Conserved Domains (4) summary

cd08754
Location:347 → 568

RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)

smart00325
Location:789 → 974

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:72 → 146

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13390
Location:993 → 1130

PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_046903858.1 → XP_046759814.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046903855.1 → XP_046759811.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046903852.1 → XP_046759808.1 rho guanine nucleotide exchange factor 12 isoform X1

UniProtKB/TrEMBL

A0A8V1ABZ6
XM_046903857.1 → XP_046759813.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046903853.1 → XP_046759809.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046903859.1 → XP_046759815.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046903856.1 → XP_046759812.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_040652161.2 → XP_040508095.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0

Conserved Domains (4) summary

cd08754
Location:243 → 464

RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)

smart00325
Location:685 → 870

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:2 → 42

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13390
Location:889 → 1026

PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_046903854.1 → XP_046759810.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

3730184..3796335 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040690186.2 → XP_040546120.1 rho guanine nucleotide exchange factor 12 isoform X3

UniProtKB/TrEMBL

A0A8V0ZZF0

Conserved Domains (4) summary

cd08754
Location:328 → 549

RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)

smart00325
Location:770 → 955

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:53 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13390
Location:974 → 1111

PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_040690184.2 → XP_040546118.1 rho guanine nucleotide exchange factor 12 isoform X2

UniProtKB/TrEMBL

F1P1Y1

Conserved Domains (4) summary

cd08754
Location:347 → 568

RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)

smart00325
Location:789 → 974

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:72 → 146

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13390
Location:993 → 1130

PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_046932494.1 → XP_046788450.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046932491.1 → XP_046788447.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046932487.1 → XP_046788443.1 rho guanine nucleotide exchange factor 12 isoform X1

UniProtKB/TrEMBL

A0A8V1ABZ6
XM_046932493.1 → XP_046788449.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046932489.1 → XP_046788445.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046932488.1 → XP_046788444.1 rho guanine nucleotide exchange factor 12 isoform X5

UniProtKB/TrEMBL

A0A8V1ABZ6
XM_046932495.1 → XP_046788451.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_046932492.1 → XP_046788448.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0
XM_040690188.2 → XP_040546122.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0

Conserved Domains (4) summary

cd08754
Location:243 → 464

RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)

smart00325
Location:685 → 870

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:2 → 42

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13390
Location:889 → 1026

PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_046932490.1 → XP_046788446.1 rho guanine nucleotide exchange factor 12 isoform X4

UniProtKB/TrEMBL

A0A8V0ZZF0