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    NEU4 sialidase 4 [ Gallus gallus (chicken) ]

    Gene ID: 429131, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NEU4provided by CGNC
    Official Full Name
    sialidase 4provided by CGNC
    Primary source
    CGNC:53560
    See related
    Ensembl:ENSGALG00010024860
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    sialidase-4
    Orthologs
    human mouse all
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    Genomic context

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    See NEU4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (4410048..4412415, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (4242931..4245298, complement)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107051864 Neighboring gene ring finger protein 168 Neighboring gene single-pass membrane protein with coiled-coil domains 1 Neighboring gene UBX domain protein 7 Neighboring gene TM4SF19 transmembrane 4 L six family member 19 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene D-2-hydroxyglutarate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. Giacopuzzi E, et al. PLoS One, 2012. PMID 22952925, Free PMC Article
    2. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. Giacopuzzi E, et al. BMC Biochem, 2011 Aug 23. PMID 21861893, Free PMC Article
    3. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. Monti E, et al. Genomics, 1999 Apr 1. PMID 10191093
    4. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Monti E, et al. Genomics, 2004 Mar. PMID 14962670
    5. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Monti E, et al. Biochem J, 2000 Jul 1. PMID 10861246, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables exo-alpha-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ganglioside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in oligosaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sialidase-4
    Names
    neuraminidase 4
    sialidase NEU4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4410048..4412415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015277126.4 → XP_015132612.2  sialidase-4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZV71, K0Q571
      Related
      ENSGALP00010037452.1, ENSGALT00010060693.1
      Conserved Domains (1) summary
      cd15482
      Location:10 → 422
      Sialidase_non-viral; Non-viral sialidases

    2. XM_025153751.3 → XP_025009519.2  sialidase-4 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A0C4
      Related
      ENSGALP00010037454.1, ENSGALT00010060695.1
      Conserved Domains (1) summary
      cd15482
      Location:90 → 502
      Sialidase_non-viral; Non-viral sialidases

    3. XM_025153750.3 → XP_025009518.2  sialidase-4 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A0C4
      Conserved Domains (1) summary
      cd15482
      Location:90 → 526
      Sialidase_non-viral; Non-viral sialidases

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4242931..4245298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040678951.2 → XP_040534885.1  sialidase-4 isoform X3

      UniProtKB/TrEMBL
      K0Q571
      Conserved Domains (1) summary
      cd15482
      Location:10 → 422
      Sialidase_non-viral; Non-viral sialidases

    2. XM_040678949.2 → XP_040534883.1  sialidase-4 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A0C4
      Conserved Domains (1) summary
      cd15482
      Location:90 → 502
      Sialidase_non-viral; Non-viral sialidases

    3. XM_040678948.2 → XP_040534882.1  sialidase-4 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A0C4
      Conserved Domains (1) summary
      cd15482
      Location:90 → 526
      Sialidase_non-viral; Non-viral sialidases
    Nucleotide Protein Strain
    Heading Accession and Version

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