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    CACNA1B calcium voltage-gated channel subunit alpha1 B [ Gallus gallus (chicken) ]

    Gene ID: 374169, updated on 3-Dec-2024

    Summary

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    Symbol
    CACNA1Bprovided by CGNC
    Full Name
    calcium voltage-gated channel subunit alpha1 Bprovided by CGNC
    Primary source
    CGNC:49068
    See related
    Ensembl:ENSGALG00010028762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    Cav2.2
    Orthologs
    human mouse all
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    Genomic context

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    See CACNA1B in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (2776250..3036456)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (2184826..2444837)

    Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene arrestin domain containing 1 Neighboring gene euchromatic histone lysine methyltransferase 1 Neighboring gene microRNA 7441 Neighboring gene collagen type I alpha 4 chain Neighboring gene solute carrier family 31 member 2 Neighboring gene family with sequence similarity 129 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long C terminal splice variant CaV2.2 identified in presynaptic membrane by mass spectrometric analysis. Gardezi SR, et al. Channels (Austin), 2010 Jan-Feb. PMID 20368691
    2. Cloning and functional expression of novel N-type Ca(2+) channel variants. Lü Q, et al. J Biol Chem, 1999 Dec 3. PMID 10574919
    3. Localization of individual calcium channels at the release face of a presynaptic nerve terminal. Haydon PG, et al. Neuron, 1994 Dec. PMID 7993621
    4. RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel. Richman RW, et al. J Biol Chem, 2005 Jan 14. PMID 15536086
    5. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein. Chan AW, et al. Channels (Austin), 2007 Jan-Feb. PMID 19170253

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGS12 binds to the SNARE-binding or "synprint" region (amino acids 726-985) in loop II-III of the Cav2.2 calcium channel alpha1 subunit
      Title: RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel.
    2. Identify of the long-splice Ca(V)2.2 in synaptosomes prepared from chick embryo brain.
      Title: Long C terminal splice variant CaV2.2 identified in presynaptic membrane by mass spectrometric analysis.
    3. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
      Title: Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables high voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent N-type calcium channel subunit alpha-1B
    Names
    CHCACHA1B
    N-type voltage-gated calcium channel alpha1B subunit ChCaChA1B
    calcium channel, voltage-dependent, L type, alpha 1B subunit
    calcium channel, voltage-dependent, N type, alpha 1B subunit
    voltage-gated calcium channel subunit alpha Cav2.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204293.2 → NP_989624.2  voltage-dependent N-type calcium channel subunit alpha-1B

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000308
      UniProtKB/TrEMBL
      Q9PUM6
      Conserved Domains (3) summary
      smart01062
      Location:1869 → 1899
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:857 → 1033
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2119 → 2276
      Transformer; Fruit fly transformer protein

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2776250..3036456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015279262.4 → XP_015134748.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1894 → 1924
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2132 → 2289
      Transformer; Fruit fly transformer protein

    2. XM_015279261.4 → XP_015134747.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1894 → 1924
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2132 → 2289
      Transformer; Fruit fly transformer protein

    3. XM_015279263.4 → XP_015134749.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1892 → 1922
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2130 → 2287
      Transformer; Fruit fly transformer protein

    4. XM_015279264.4 → XP_015134750.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1890 → 1920
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2128 → 2285
      Transformer; Fruit fly transformer protein

    5. XM_015279266.4 → XP_015134752.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1888 → 1918
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2126 → 2283
      Transformer; Fruit fly transformer protein

    6. XM_015279265.4 → XP_015134751.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1888 → 1918
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2126 → 2283
      Transformer; Fruit fly transformer protein

    7. XM_025156019.3 → XP_025011787.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Related
      ENSGALP00010042870.1, ENSGALT00010069609.1
      Conserved Domains (3) summary
      smart01062
      Location:1871 → 1901
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:857 → 1033
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2109 → 2266
      Transformer; Fruit fly transformer protein

    8. XM_015279276.4 → XP_015134762.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

      UniProtKB/TrEMBL
      Q9PUM5
      Conserved Domains (2) summary
      smart01062
      Location:1869 → 1899
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:857 → 1033
      PRK12678; transcription termination factor Rho; Provisional

    9. XM_015279270.4 → XP_015134756.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1867 → 1897
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:857 → 1033
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2105 → 2262
      Transformer; Fruit fly transformer protein

    10. XM_015279267.4 → XP_015134753.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1883 → 1913
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:867 → 1043
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2121 → 2278
      Transformer; Fruit fly transformer protein

    11. XM_015279268.4 → XP_015134754.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

      UniProtKB/TrEMBL
      Q9PW47
      Conserved Domains (3) summary
      smart01062
      Location:1858 → 1888
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:846 → 1022
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2108 → 2265
      Transformer; Fruit fly transformer protein

    12. XM_015279277.4 → XP_015134763.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X19

      UniProtKB/TrEMBL
      Q9PW46
      Conserved Domains (2) summary
      smart01062
      Location:1858 → 1888
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:846 → 1022
      PRK12678; transcription termination factor Rho; Provisional

    13. XM_015279269.4 → XP_015134755.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1869 → 1899
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:853 → 1029
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2107 → 2264
      Transformer; Fruit fly transformer protein

    14. XM_015279273.4 → XP_015134759.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

      UniProtKB/TrEMBL
      A0A8V1AJW5
      Conserved Domains (3) summary
      smart01062
      Location:1846 → 1876
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:832 → 1008
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2084 → 2241
      Transformer; Fruit fly transformer protein

    15. XM_015279272.4 → XP_015134758.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

      UniProtKB/TrEMBL
      Q9PW45
      Conserved Domains (3) summary
      smart01062
      Location:1844 → 1874
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:832 → 1008
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2094 → 2251
      Transformer; Fruit fly transformer protein

    16. XM_015279278.4 → XP_015134764.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X20

      UniProtKB/TrEMBL
      Q9PW44
      Conserved Domains (2) summary
      smart01062
      Location:1844 → 1874
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:832 → 1008
      PRK12678; transcription termination factor Rho; Provisional

    17. XM_025156020.3 → XP_025011788.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

      UniProtKB/TrEMBL
      Q9PW45
      Conserved Domains (3) summary
      smart01062
      Location:1842 → 1872
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:832 → 1008
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2080 → 2237
      Transformer; Fruit fly transformer protein

    18. XM_015279271.4 → XP_015134757.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

      UniProtKB/TrEMBL
      Q9PUM4
      Conserved Domains (3) summary
      smart01062
      Location:1858 → 1888
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:842 → 1018
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2096 → 2253
      Transformer; Fruit fly transformer protein

    19. XM_015279274.4 → XP_015134760.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

      UniProtKB/TrEMBL
      Q9PUM4
      Related
      ENSGALP00010042865.1, ENSGALT00010069604.1
      Conserved Domains (3) summary
      smart01062
      Location:1833 → 1863
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:821 → 997
      PRK12678; transcription termination factor Rho; Provisional
      pfam06495
      Location:2083 → 2240
      Transformer; Fruit fly transformer protein

    20. XM_015279279.4 → XP_015134765.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X21

      UniProtKB/TrEMBL
      Q9PUM3
      Conserved Domains (2) summary
      smart01062
      Location:1833 → 1863
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:821 → 997
      PRK12678; transcription termination factor Rho; Provisional

    21. XM_015279275.4 → XP_015134761.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

      UniProtKB/TrEMBL
      Q9PUM5
      Conserved Domains (2) summary
      smart01062
      Location:1894 → 1924
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      PRK12678
      Location:878 → 1054
      PRK12678; transcription termination factor Rho; Provisional

    RNA

    1. XR_001464423.4 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      2184826..2444837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928648.1 → XP_046784604.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

      UniProtKB/TrEMBL
      A0A8V1AJW5

    2. XM_046928646.1 → XP_046784602.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

      UniProtKB/TrEMBL
      A0A8V1AJW5

    3. XM_046928649.1 → XP_046784605.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

      UniProtKB/TrEMBL
      A0A8V1AJW5

    4. XM_046928650.1 → XP_046784606.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

      UniProtKB/TrEMBL
      A0A8V1AJW5

    5. XM_046928652.1 → XP_046784608.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

      UniProtKB/TrEMBL
      Q9PUM6

    6. XM_046928651.1 → XP_046784607.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

      UniProtKB/TrEMBL
      A0A8V1AJW5

    7. XM_046928654.1 → XP_046784610.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

      UniProtKB/TrEMBL
      A0A8V1AJW5

    8. XM_046928665.1 → XP_046784621.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

      UniProtKB/TrEMBL
      Q9PUM5

    9. XM_046928658.1 → XP_046784614.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

      UniProtKB/TrEMBL
      A0A8V1AJW5

    10. XM_046928653.1 → XP_046784609.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

      UniProtKB/TrEMBL
      A0A8V1AJW5

    11. XM_046928655.1 → XP_046784611.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

      UniProtKB/TrEMBL
      Q9PW47

    12. XM_046928666.1 → XP_046784622.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X19

      UniProtKB/TrEMBL
      Q9PW46

    13. XM_046928656.1 → XP_046784612.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

      UniProtKB/TrEMBL
      A0A8V1AJW5

    14. XM_046928661.1 → XP_046784617.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

      UniProtKB/TrEMBL
      A0A8V1AJW5

    15. XM_046928660.1 → XP_046784616.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

      UniProtKB/TrEMBL
      Q9PW45

    16. XM_046928667.1 → XP_046784623.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X20

      UniProtKB/TrEMBL
      Q9PW44

    17. XM_046928663.1 → XP_046784619.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

      UniProtKB/TrEMBL
      Q9PW45

    18. XM_046928659.1 → XP_046784615.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

      UniProtKB/TrEMBL
      Q9PUM4

    19. XM_046928662.1 → XP_046784618.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

      UniProtKB/TrEMBL
      Q9PUM4

    20. XM_046928668.1 → XP_046784624.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X21

      UniProtKB/TrEMBL
      Q9PUM3

    21. XM_046928664.1 → XP_046784620.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

      UniProtKB/TrEMBL
      Q9PUM5

    RNA

    1. XR_006936398.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73706.1 GenPept UniProtKB/Swiss-Prot:O73706

    Gene LinkOut

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