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    LEF1 lymphoid enhancer binding factor 1 [ Gallus gallus (chicken) ]

    Gene ID: 395865, updated on 3-Dec-2024

    Summary

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    Symbol
    LEF1provided by CGNC
    Full Name
    lymphoid enhancer binding factor 1provided by CGNC
    Primary source
    CGNC:7997
    See related
    Ensembl:ENSGALG00010005587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    LEF-1
    Orthologs
    human mouse all
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    Genomic context

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    See LEF1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (37449291..37503977)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (37402546..37457178)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124418363 Neighboring gene ribosomal protein L34 Neighboring gene uncharacterized LOC121110572 Neighboring gene uncharacterized LOC107051763 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene cytochrome P450 family 2 subfamily U member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered PITX2 and LEF1 gene expression in the cadmium-induced omphalocele in the chick model. Doi T, et al. Pediatr Surg Int, 2011 May. PMID 21259014
    2. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Kengaku M, et al. Science, 1998 May 22. PMID 9596583
    3. Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis. Abu-Elmagd M, et al. Dev Biol, 2010 Jan 15. PMID 19850024
    4. Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Cho SH, et al. Development, 2006 Aug. PMID 16854977
    5. Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Kubo F, et al. Development, 2003 Feb. PMID 12490564

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of PITX2 and LEF1 genes may interfere with ventral body wall formation in Cd chick model causing omphalocele by disrupting somite myogenesis.
      Title: Altered PITX2 and LEF1 gene expression in the cadmium-induced omphalocele in the chick model.
    2. Wnt/Lef1 signaling regulates epaxial myogenesis via Pitx2.
      Title: Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis.
    3. Knockout of LEF1 in the developing peripheral eye lead to partial loss of the iris and ciliary body hypoplasia.
      Title: Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lymphoid enhancer-binding factor 1
    Names
    lymphiod enhancer binding factor 1
    transcription factor LEF-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398055.1 → NP_001384984.1  lymphoid enhancer-binding factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000073
      UniProtKB/TrEMBL
      A0A3Q3B1W2, A0A8V0XMK8
      Related
      ENSGALP00010007939.1, ENSGALT00010013390.1
      Conserved Domains (2) summary
      cd01388
      Location:296 → 367
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:1 → 211
      CTNNB1_binding; N-terminal CTNNB1 binding

    2. NM_001398056.1 → NP_001384985.1  lymphoid enhancer-binding factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000073
      UniProtKB/TrEMBL
      A0A8V0XMK8, A0A8V0XV79
      Related
      ENSGALP00010007934.1, ENSGALT00010013383.1
      Conserved Domains (2) summary
      cd01388
      Location:296 → 367
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:1 → 211
      CTNNB1_binding; N-terminal CTNNB1 binding

    3. NM_001398057.1 → NP_001384986.1  lymphoid enhancer-binding factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000073
      UniProtKB/TrEMBL
      A0A8V0XMK8, A0A8V0XSL5
      Related
      ENSGALP00010007942.1, ENSGALT00010013396.1
      Conserved Domains (2) summary
      cd01388
      Location:268 → 339
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:1 → 211
      CTNNB1_binding; N-terminal CTNNB1 binding

    4. NM_001398058.1 → NP_001384987.1  lymphoid enhancer-binding factor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000073
      UniProtKB/TrEMBL
      A0A8V0XMK8
      Related
      ENSGALP00010007927.1, ENSGALT00010013374.1

    5. NM_205013.3 → NP_990344.1  lymphoid enhancer-binding factor 1 isoform 4

      See identical proteins and their annotated locations for NP_990344.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000073
      UniProtKB/TrEMBL
      A0A8V0XMK8, O93345
      Related
      ENSGALP00010007932.1, ENSGALT00010013381.1
      Conserved Domains (2) summary
      cd01388
      Location:268 → 339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 211
      CTNNB1_binding; N-terminal CTNNB1 binding

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      37449291..37503977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      37402546..37457178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials