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    JAG1 jagged canonical Notch ligand 1 [ Gallus gallus (chicken) ]

    Gene ID: 396043, updated on 3-Dec-2024

    Summary

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    Symbol
    JAG1provided by CGNC
    Full Name
    jagged canonical Notch ligand 1provided by CGNC
    Primary source
    CGNC:6856
    See related
    Ensembl:ENSGALG00010018226
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See JAG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (13191920..13227987)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (13104240..13140303)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110388 Neighboring gene uncharacterized LOC107052861 Neighboring gene microRNA 1641 Neighboring gene uncharacterized LOC112532057 Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC124417870 Neighboring gene MKKS centrosomal shuttling protein Neighboring gene p21 (RAC1) activated kinase 5 Neighboring gene synaptosome associated protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Myat A, et al. Dev Biol, 1996 Mar 15. PMID 8631496
    2. Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification. Neves J, et al. Development, 2011 Feb. PMID 21266409
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein jagged-1
    Names
    C-Serate-1 protein
    jagged 1 (Alagille syndrome)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13191920..13227987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_415035.8 → XP_415035.4  protein jagged-1 isoform X1

      UniProtKB/TrEMBL
      E1BTW5, Q90819
      Related
      ENSGALP00010026180.1, ENSGALT00010044034.1
      Conserved Domains (5) summary
      smart00215
      Location:860 → 928
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:484 → 520
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:745 → 775
      EGF; EGF-like domain
      pfam01414
      Location:164 → 226
      DSL; Delta serrate ligand
      pfam07657
      Location:29 → 104
      MNNL; N-terminus of Notch ligand

    2. XM_046939525.1 → XP_046795481.1  protein jagged-1 isoform X2

      UniProtKB/TrEMBL
      Q90819

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13104240..13140303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040668033.2 → XP_040523967.1  protein jagged-1 isoform X1

      UniProtKB/TrEMBL
      E1BTW5, Q90819
      Conserved Domains (5) summary
      smart00215
      Location:860 → 928
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:484 → 520
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:745 → 775
      EGF; EGF-like domain
      pfam01414
      Location:164 → 226
      DSL; Delta serrate ligand
      pfam07657
      Location:29 → 104
      MNNL; N-terminus of Notch ligand

    2. XM_046915030.1 → XP_046770986.1  protein jagged-1 isoform X2

      UniProtKB/TrEMBL
      Q90819
    Nucleotide Protein
    Heading Accession and Version

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