CHRNA6 cholinergic receptor nicotinic alpha 6 subunit [Gallus gallus (chicken)] - Gene

Summary

Symbol: CHRNA6provided by CGNC
Full Name: cholinergic receptor nicotinic alpha 6 subunitprovided by CGNC
Primary source: CGNC:49753
See related: Ensembl:ENSGALG00010013675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Z

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (54269217..54300031)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (54269217..54300031)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-6

Names: alpha 6 nicotinic acetylcholine receptor subunit; cholinergic receptor, nicotinic, alpha 6 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205364.2 → NP_990695.1 neuronal acetylcholine receptor subunit alpha-6 precursor

See identical proteins and their annotated locations for NP_990695.1

Status: VALIDATED

Source sequence(s)

JAENSK010000095

UniProtKB/Swiss-Prot

P49581, Q90709

UniProtKB/TrEMBL

A0A8V0YLH7

Related

ENSGALP00010019461.1, ENSGALT00010032874.1

Conserved Domains (3) summary

TIGR00860
Location:17 → 487

LIC; Cation transporter family protein

pfam02931
Location:34 → 240

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:247 → 486

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

54269217..54300031

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046905272.1 → XP_046761228.1 neuronal acetylcholine receptor subunit alpha-6 isoform X1

UniProtKB/Swiss-Prot

P49581, Q90709

UniProtKB/TrEMBL

A0A8V0YLH7
XM_046905273.1 → XP_046761229.1 neuronal acetylcholine receptor subunit alpha-6 isoform X1

UniProtKB/Swiss-Prot

P49581, Q90709

UniProtKB/TrEMBL

A0A8V0YLH7
XM_025144691.3 → XP_025000459.2 neuronal acetylcholine receptor subunit alpha-6 isoform X3

Conserved Domains (3) summary

TIGR00860
Location:56 → 408

LIC; Cation transporter family protein

cd03558
Location:79 → 93

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:39 → 160

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_040655452.2 → XP_040511386.1 neuronal acetylcholine receptor subunit alpha-6 isoform X2

UniProtKB/Swiss-Prot

P49581, Q90709

Conserved Domains (3) summary

TIGR00860
Location:1 → 408

LIC; Cation transporter family protein

cd03558
Location:79 → 93

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:1 → 160

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

RNA

XR_005842616.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

54269217..54300031

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046934873.1 → XP_046790829.1 neuronal acetylcholine receptor subunit alpha-6 isoform X1

UniProtKB/Swiss-Prot

P49581, Q90709

UniProtKB/TrEMBL

A0A8V0YLH7
XM_046934874.1 → XP_046790830.1 neuronal acetylcholine receptor subunit alpha-6 isoform X1

UniProtKB/Swiss-Prot

P49581, Q90709

UniProtKB/TrEMBL

A0A8V0YLH7
XM_046934876.1 → XP_046790832.1 neuronal acetylcholine receptor subunit alpha-6 isoform X3
XM_046934875.1 → XP_046790831.1 neuronal acetylcholine receptor subunit alpha-6 isoform X2

UniProtKB/Swiss-Prot

P49581, Q90709