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    GNAS GNAS complex locus [ Gallus gallus (chicken) ]

    Gene ID: 419313, updated on 17-Aug-2024

    Summary

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    Symbol
    GNASprovided by CGNC
    Full Name
    GNAS complex locusprovided by CGNC
    Primary source
    CGNC:50967
    See related
    Ensembl:ENSGALG00010016384
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GNASXL; G-alpha-S
    Orthologs
    human mouse all
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    Genomic context

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    See GNAS in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (11257331..11388078, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (11044702..11175437, complement)

    Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene microRNA 6597 Neighboring gene cathepsin Z Neighboring gene negative elongation factor complex member C/D Neighboring gene uncharacterized LOC121107349 Neighboring gene microRNA 6564 Neighboring gene aminopeptidase-like 1 Neighboring gene syntaxin 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. Cairns DM, et al. J Clin Invest, 2013 Aug. PMID 23863715, Free PMC Article
    2. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-2 adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mu-type opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(s) subunit alpha
    Names
    guanine nucleotide-binding protein G(s) subunit alpha XL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11257331..11388078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025142352.3 → XP_024998120.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q2TWD9
      Related
      ENSGALP00010022770.1, ENSGALT00010039463.1
      Conserved Domains (1) summary
      cd00066
      Location:79 → 411
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. XM_046903073.1 → XP_046759029.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    3. XM_046903071.1 → XP_046759027.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    4. XM_025142353.3 → XP_024998121.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A1D5PDG4
      Related
      ENSGALP00010022767.1, ENSGALT00010039457.1
      Conserved Domains (1) summary
      cd00066
      Location:41 → 373
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    5. XM_046903070.1 → XP_046759026.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X5

    6. XM_025142355.3 → XP_024998123.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

      Conserved Domains (1) summary
      cd00066
      Location:1 → 314
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    7. XM_025142354.3 → XP_024998122.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8V0YVI5
      Related
      ENSGALP00010022762.1, ENSGALT00010039451.1
      Conserved Domains (1) summary
      cd00066
      Location:17 → 343
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    8. XM_046903072.1 → XP_046759028.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    9. XM_040651033.2 → XP_040506967.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

      Conserved Domains (1) summary
      cd00066
      Location:1 → 168
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    10. XM_046903074.1 → XP_046759030.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      11044702..11175437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040688340.2 → XP_040544274.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q2TWD9
      Conserved Domains (1) summary
      cd00066
      Location:79 → 411
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. XM_046931000.1 → XP_046786956.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    3. XM_046930998.1 → XP_046786954.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    4. XM_040688341.2 → XP_040544275.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A1D5PDG4
      Conserved Domains (1) summary
      cd00066
      Location:41 → 373
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    5. XM_046930997.1 → XP_046786953.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X5

    6. XM_040688343.2 → XP_040544277.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

      Conserved Domains (1) summary
      cd00066
      Location:1 → 314
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    7. XM_040688342.2 → XP_040544276.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8V0YVI5
      Conserved Domains (1) summary
      cd00066
      Location:17 → 343
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    8. XM_046930999.1 → XP_046786955.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    9. XM_040688344.2 → XP_040544278.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

      Conserved Domains (1) summary
      cd00066
      Location:1 → 168
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    10. XM_046931001.1 → XP_046786957.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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