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    CHUK component of inhibitor of nuclear factor kappa B kinase complex [ Gallus gallus (chicken) ]

    Gene ID: 423669, updated on 3-Dec-2024

    Summary

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    Official Symbol
    CHUKprovided by CGNC
    Official Full Name
    component of inhibitor of nuclear factor kappa B kinase complexprovided by CGNC
    Primary source
    CGNC:52021
    See related
    Ensembl:ENSGALG00010008527
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    IKKA
    Orthologs
    human mouse all
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    Genomic context

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    See CHUK in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (10006760..10029624)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (9890647..9913512)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene leukocyte ribonuclease A-2 Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene small nucleolar RNA SNORA12 Neighboring gene ER lipid raft associated 1 Neighboring gene ADAM metallopeptidase domain 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Lynn DJ, et al. Vet Immunol Immunopathol, 2003 Jun 20. PMID 12814703
    2. Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken. Rengaraj D, et al. Vet Immunol Immunopathol, 2016 Feb. PMID 26872625
    3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables IkappaB kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IkappaB kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit alpha
    Names
    IKK-A
    IKK-alpha
    NFKBIKA
    conserved helix-loop-helix ubiquitous kinase
    i kappa-B kinase alpha
    ikBKA
    ikappaB kinase
    nuclear factor NF-kappa-B inhibitor kinase alpha
    NP_001012922.2
    XP_015134161.1
    XP_046776088.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012904.2 → NP_001012922.2  inhibitor of nuclear factor kappa-B kinase subunit alpha

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000227
      UniProtKB/Swiss-Prot
      Q5ZJB4
      UniProtKB/TrEMBL
      A0A8V0Y749
      Related
      ENSGALP00010011850.1, ENSGALT00010020403.1
      Conserved Domains (2) summary
      cd14039
      Location:35 → 323
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
      cd17046
      Location:325 → 401
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10006760..10029624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015278675.4 → XP_015134161.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0XUD8
      Related
      ENSGALP00010011854.1, ENSGALT00010020434.1
      Conserved Domains (2) summary
      smart00220
      Location:29 → 301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14039
      Location:35 → 323
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      9890647..9913512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920132.1 → XP_046776088.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0XUD8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZJB4.1 GenPept UniProtKB/Swiss-Prot:Q5ZJB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.